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AB279366

Anti-MOX1/MEOX1 antibody [OTI5D8]

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(2 Publications)

Mouse Monoclonal MOX1/MEOX1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MEOX1.

View Alternative Names

MOX1, MEOX1, Homeobox protein MOX-1, Mesenchyme homeobox 1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOX1/MEOX1 antibody [OTI5D8] (AB279366)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOX1/MEOX1 antibody [OTI5D8] (AB279366)

Paraffin embedded human tonsil tissue stained for MEOX1 using ab279366 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer, pH8.5, at 120°C for 3 minutes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOX1/MEOX1 antibody [OTI5D8] (AB279366)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOX1/MEOX1 antibody [OTI5D8] (AB279366)

Paraffin embedded human lymphoma tissue stained for MEOX1 using ab279366 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer, pH8.5, at 120°C for 3 minutes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOX1/MEOX1 antibody [OTI5D8] (AB279366)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOX1/MEOX1 antibody [OTI5D8] (AB279366)

Paraffin embedded human breast tissue stained for MEOX1 using ab279366 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer, pH8.5, at 120°C for 3minutes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOX1/MEOX1 antibody [OTI5D8] (AB279366)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOX1/MEOX1 antibody [OTI5D8] (AB279366)

Paraffin embedded human endometrium tissue stained for MEOX1 using ab279366 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer, pH8.5, at 120°C for 3 minutes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI5D8

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MEOX1.

P50221

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MOX1 also known as MEOX1 or mesenchyme homeobox 1 is a homeobox protein. The molecular weight of MEOX1 is approximately 34 kDa. This protein functions as a transcription factor meaning it binds to specific DNA sequences to regulate gene expression. MEOX1 expresses mainly in the mesoderm during embryonic development and in various adult tissues including muscles and skin. Its activity is critical for tissue formation particularly in the developing mesodermal tissues.
Biological function summary

MEOX1 plays a role in segment identity and myogenesis. It helps direct the formation of somites which are essential precursor structures for the vertebral column and skeletal muscles. MEOX1 does not function alone; it often interacts with other homeobox proteins forming complexes that finely control the transcription of genes essential for development. This interaction ensures proper segment patterning and muscle differentiation important for normal embryonic development.

Pathways

MEOX1 has an essential place in the Wnt signaling and Notch signaling pathways. These pathways are significant during embryogenesis for the regulation of development and cell fate decisions. In these pathways MEOX1 interacts with proteins like TCF/LEF family members and the Notch intracellular domain. The integration of MEOX1 into these pathways underpins its ability to influence various developmental processes indicating its extensive regulatory potential.

MEOX1 mutations link to Klippel-Feil syndrome a disorder characterized by the abnormal fusion of spinal vertebrae. This connection highlights the protein's role in vertebral segmentation. Additionally abnormal MEOX1 activity may contribute to muscle development disorders implicating its involvement in myogenic pathways. While not directly connected proteins like PAX1 and PAX3 also relate to these conditions sharing roles in skeletal and muscle development supporting coordinated gene networks that maintain normal anatomical structures.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed : 23290072, PubMed : 24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis : specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
See full target information MEOX1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Neoplasma 70:777-786 PubMed38247333

2024

CHAC1 promotes cell ferroptosis and enhances radiation sensitivity in thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xinlin Yang,Miao Zhang,Wei Xia,Zhongchao Mai,Ying Ye,Bin Zhao,Yanan Song

Environmental toxicology 37:504-513 PubMed34837450

2021

MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell-cycle checkpoint gene CCNB1.

Applications

Unspecified application

Species

Unspecified reactive species

Xie Xiao,Bi Rui,Hu Rui,Mei Ju,Liu Hongtao
View all publications
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