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AB153807

Anti-MOXD1/MOX antibody

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(2 Publications)

Rabbit Polyclonal MOXD1/MOX antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MOXD1 aa 150-450.

View Alternative Names

MOX, UNQ2493/PRO5780, MOXD1, DBH-like monooxygenase protein 1, Monooxygenase X

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOXD1/MOX antibody (AB153807)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOXD1/MOX antibody (AB153807)

Immunohistochemical analysis of paraffin-embedded Human MCF7 xenograft tissue labeling MOXD1/MOX with ab153807 at 1/250 dilution.

Western blot - Anti-MOXD1/MOX antibody (AB153807)
  • WB

Unknown

Western blot - Anti-MOXD1/MOX antibody (AB153807)

7.5% SDS PAGE

All lanes:

Western blot - Anti-MOXD1/MOX antibody (ab153807) at 1/1000 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 57 kDa,70 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MOXD1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

Q6UVY6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MOXD1 also known as monooxygenase DBH-like 1 or MOX is a member of the copper type II ascorbate-dependent monooxygenase family. It functions mechanistically by catalyzing the hydroxylation of its substrates a process essential for certain biochemical conversions. The mass of MOXD1 is approximately 82 kDa. MOXD1 expresses prominently in the central nervous system particularly in the brain and can also be found in other tissues at varying levels.
Biological function summary

The enzyme MOXD1 plays a role in neuroactive substrate modifications contributing to neurotransmitter biosynthesis. MOXD1 does not form a known complex but interacts with copper ions that act as cofactors which are necessary for its enzymatic activity. The action of MOXD1 impacts cellular processes by regulating key elements within the neurochemical framework aiding in overall neuronal function.

Pathways

MOXD1 integrates into the catecholamine biosynthetic pathway. This pathway is significant for the production of amine neurotransmitters such as dopamine and norepinephrine. MOXD1 relates to dopamine beta-hydroxylase (DBH) another enzyme in this pathway that also uses copper as a cofactor. Both enzymes contribute to the maintenance of catecholamine balance in the nervous system.

MOXD1 shows connections with neurological conditions such as depression and neurodegenerative diseases. Changes in MOXD1 expression or function may influence neurotransmitter levels potentially impacting mood and cognitive functions. Studies have suggested a relationship between MOXD1 and dopamine-related disorders through its connection to DBH which has been implicated in the pathophysiology of certain mental health conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MOXD1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 19:1642-1661 PubMed36184612

2022

The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10.

Applications

Unspecified application

Species

Unspecified reactive species

Sang Mi Shim,Ha Rim Choi,Soon Chul Kwon,Hye Yeon Kim,Ki Woon Sung,Eui Jung Jung,Su Ran Mun,Tae Hyun Bae,Dong Hyun Kim,Yeon Sung Son,Chan Hoon Jung,Jihoon Lee,Min Jae Lee,Joo-Won Park,Yong Tae Kwon

The Journal of biological chemistry 289:6791-8 PubMed24403074

2014

Modification of hyaluronan by heavy chains of inter-α-inhibitor in idiopathic pulmonary arterial hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Mark E Lauer,Metin Aytekin,Suzy A Comhair,Jacqueline Loftis,Liping Tian,Carol F Farver,Vincent C Hascall,Raed A Dweik
View all publications
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Product promise

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