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Rabbit Polyclonal MOXD1/MOX antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MOXD1 aa 150-450.

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Images

Western blot - Anti-MOXD1/MOX antibody (AB153807), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOXD1/MOX antibody (AB153807), expandable thumbnail

Publications

  • Autophagy 19:1642-16612022
    The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Sang Mi Shim,Ha Rim Choi,Soon Chul Kwon,Hye Yeon Kim,Ki Woon Sung,Eui Jung Jung,Su Ran Mun,Tae Hyun Bae,Dong Hyun Kim,Yeon Sung Son,Chan Hoon Jung,Jihoon Lee,Min Jae Lee,Joo-Won Park,Yong Tae Kwon
    PubMed 36184612

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human MOXD1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information. Database link Q6UVY6

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PWB
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Alternative names

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Rabbit Polyclonal MOXD1/MOX antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MOXD1 aa 150-450.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human MOXD1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information. Database link Q6UVY6
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Activity summary

MOXD1 also known as monooxygenase DBH-like 1 or MOX is a member of the copper type II ascorbate-dependent monooxygenase family. It functions mechanistically by catalyzing the hydroxylation of its substrates a process essential for certain biochemical conversions. The mass of MOXD1 is approximately 82 kDa. MOXD1 expresses prominently in the central nervous system particularly in the brain and can also be found in other tissues at varying levels.

Biological function summary

The enzyme MOXD1 plays a role in neuroactive substrate modifications contributing to neurotransmitter biosynthesis. MOXD1 does not form a known complex but interacts with copper ions that act as cofactors which are necessary for its enzymatic activity. The action of MOXD1 impacts cellular processes by regulating key elements within the neurochemical framework aiding in overall neuronal function.

Pathways

MOXD1 integrates into the catecholamine biosynthetic pathway. This pathway is significant for the production of amine neurotransmitters such as dopamine and norepinephrine. MOXD1 relates to dopamine beta-hydroxylase (DBH) another enzyme in this pathway that also uses copper as a cofactor. Both enzymes contribute to the maintenance of catecholamine balance in the nervous system.

Associated diseases and disorders

MOXD1 shows connections with neurological conditions such as depression and neurodegenerative diseases. Changes in MOXD1 expression or function may influence neurotransmitter levels potentially impacting mood and cognitive functions. Studies have suggested a relationship between MOXD1 and dopamine-related disorders through its connection to DBH which has been implicated in the pathophysiology of certain mental health conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Western blot - Anti-MOXD1/MOX antibody (ab153807), expandable thumbnail

    Western blot - Anti-MOXD1/MOX antibody (ab153807)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-MOXD1/MOX antibody (ab153807) at 1/1000 dilution

    All lanes: A431 whole cell lysate at 30 µg

    Predicted band size: 57 kDa, 70 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOXD1/MOX antibody (ab153807), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOXD1/MOX antibody (ab153807)

    Immunohistochemical analysis of paraffin-embedded Human MCF7 xenograft tissue labeling MOXD1/MOX with ab153807 at 1/250 dilution.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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