Rabbit Polyclonal MPEG1 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 4 publications.
pH: 6.5
Preservative: 0.1% Sodium azide
Constituents: PBS
| WB | |
|---|---|
| Mouse | Expected |
| Rat | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide. Macrophage-expressed gene 1 protein, processed form. Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming.
Macrophage-expressed gene 1 protein, Macrophage gene 1 protein, Mpg-1, Perforin-2, P-2
Rabbit Polyclonal MPEG1 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 4 publications.
pH: 6.5
Preservative: 0.1% Sodium azide
Constituents: PBS
ab25146 recognises Mpg-1 (macrophage-specific gene, MSG, MPS1).
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MPEG1 also known as Macrophage Expressed Gene 1 is a protein with a molecular mass of approximately 71 kDa. It shows expression mainly in macrophages and other immune-related cells. MPEG1 belongs to the perforin-like protein family and acts by forming pores in target membranes a critical mechanical action of its function. This allows MPEG1 to contribute to immune defense by enabling the transfer of antimicrobial substances across cellular membranes.
MPEG1 participates in the immune response and exhibits bactericidal activity. It is involved in innate immunity and works closely with other proteins to eliminate pathogens. In addition to its individual function it may exist within larger protein complexes that enhance its bactericidal properties in immune cells. This involvement suggests a significant role in acting against microbial infections and influencing immune system dynamics.
Several major processes integrate the functions of MPEG1. It plays a role in the antimicrobial pathway by interacting with other proteins such as P2X7 which is part of the purinergic signaling pathway. By forming pores MPEG1 aids in pathogen degradation and modulates inflammatory responses. MPEG1's interaction within these pathways suggests it connects with cellular mechanisms of microbial clearance and immune regulation.
Abnormalities in MPEG1 function correlate with conditions such as chronic inflammatory diseases and some immune deficiency disorders. Altered MPEG1 expression or activity can impact its role in controlling infection and inflammation leading to relevant health issues. Besides proteins like NLRC4 are connected with MPEG1 in biological processes related to disease states indicating a multilayered interaction in maintaining host defense and controlling inflammatory responses.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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