Rabbit Polyclonal MPP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MPP1 aa 200-400.
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Publications
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- Nature communications 8:4232017Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNai-Jia Huang,Novalia Pishesha,Jean Mukherjee,Sicai Zhang,Rhogerry Deshycka,Valentino Sudaryo,Min Dong,Charles B Shoemaker,Harvey F LodishPubMed 28871080
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human MPP1 aa 200-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q00013
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Cow | Predicted | Predicted |
| Rabbit | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rabbit, Cow | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rabbit, Cow | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
Alternative names
DXS552E, EMP55, MPP1, 55 kDa erythrocyte membrane protein, p55
Recommended products
Rabbit Polyclonal MPP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MPP1 aa 200-400.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human MPP1 aa 200-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q00013
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The MPP1 protein also known as Membrane Palmitoylated Protein 1 acts as a part of the membrane-associated guanylate kinase (MAGUK) family. This protein has a molecular mass of around 55 kDa. MPP1 expresses mainly in erythrocytes the cells that carry oxygen in the blood. Functionally it plays a role in maintaining cell shape and stability by contributing to the cytoskeletal structure. It localizes at the plasma membrane and interacts with other proteins to fulfill its functions.
- Biological function summary
In various cell types MPP1 supports cell adhesion and communication. As a complex-forming protein MPP1 interacts with spectrin and actin contributing to the structural organization of cell membranes. MPP1 regulates interactions within the cellular environment influencing cellular signaling and mechanical integrity. By establishing these connections it helps maintain cell shape and facilitate cell signaling processes.
- Pathways
Several interactions actively involve MPP1. Within the pathways regulating cell shape MPP1 contributes to the RhoA signaling pathway important for cytoskeletal organization. Furthermore MPP1 closely works with proteins like Ezrin to support plasma membrane stability and intracellular communication. These interactions are significant for maintaining normal cellular junctions and morphology.
- Associated diseases and disorders
MPP1 links to specific conditions with impacts on erythrocyte function. It has been implicated in hereditary spherocytosis a disorder affecting red blood cell stability and causing anemia. MPP1 also interacts with the protein Ankyrin an important component in maintaining erythrocyte membrane structure. These associations highlight the importance of MPP1 in blood-related diseases marking it as an important target for understanding membrane disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-MPP1 antibody (ab96255)
10% SDS-PAGE
All lanes: Western blot - Anti-MPP1 antibody (ab96255) at 1/1000 dilution
All lanes: HeLa whole cell lysate at 30 µg
Predicted band size: 52 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPP1 antibody (ab96255)
Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using ab96255 antibody at 1/100 dilution.
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