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AB231634

Anti-MPP2/DLG2 antibody

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(4 Publications)

Rabbit Polyclonal MPP2/DLG2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Mpp2 aa 1-250.

View Alternative Names

Dlgh2, Mpp2, MAGUK p55 subfamily member 2, Discs large homolog 2, Protein MPP2

6 Images
Immunocytochemistry/ Immunofluorescence - Anti-MPP2/DLG2 antibody (AB231634)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MPP2/DLG2 antibody (AB231634)

A4549 (Human lung carcinoma cell line) cells stained for MPP2/DLG2 using ab231634 at 20 μg/ml in ICC/IF.

Western blot - Anti-MPP2/DLG2 antibody (AB231634)
  • WB

Supplier Data

Western blot - Anti-MPP2/DLG2 antibody (AB231634)

All lanes:

Western blot - Anti-MPP2/DLG2 antibody (ab231634) at 2 µg/mL

All lanes:

Mouse cerebrum lysate

Predicted band size: 62 kDa

false

Western blot - Anti-MPP2/DLG2 antibody (AB231634)
  • WB

Supplier Data

Western blot - Anti-MPP2/DLG2 antibody (AB231634)

All lanes:

Western blot - Anti-MPP2/DLG2 antibody (ab231634) at 2 µg/mL

All lanes:

Mouse kidney lysate

Predicted band size: 35 kDa,42 kDa,45 kDa,47 kDa,50 kDa,62 kDa,69 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPP2/DLG2 antibody (AB231634)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPP2/DLG2 antibody (AB231634)

Formalin-fixed, paraffin-embedded mouse esophagus tissue stained for MPP2/DLG2 using ab231634 at 10 μg/ml in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPP2/DLG2 antibody (AB231634)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MPP2/DLG2 antibody (AB231634)

Formalin-fixed, paraffin-embedded mouse esophagus tissue stained for MPP2/DLG2 using ab231634 at 10 μg/ml in immunohistochemical analysis.

Western blot - Anti-MPP2/DLG2 antibody (AB231634)
  • WB

Supplier Data

Western blot - Anti-MPP2/DLG2 antibody (AB231634)

All lanes:

Western blot - Anti-MPP2/DLG2 antibody (ab231634) at 2 µg/mL

All lanes:

Recombinant mouse MPP2/DLG2 protein

Predicted band size: 62 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Mouse Mpp2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9WV34

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5-20 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab231634 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MPP2 also known as DLG2 (Discs Large Homolog 2) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. It plays a role in maintaining cell polarity and organizing signal complexes at cell junctions. This protein has a mass of approximately 85 kDa. MPP2/DLG2 expresses mainly in the brain particularly in neuronal cells where it contributes to synaptic transmission and plasticity.
Biological function summary

The DLG2 protein acts as a scaffolding protein that organizes other proteins within the synaptic membrane at excitatory synapses. It is part of the heteromeric complex that includes other synaptic proteins facilitating interactions between NMDA receptors and various signaling molecules. By stabilizing these protein interactions DLG2 influences synaptic strength and cellular communication pathways.

Pathways

DLG2 is involved in the regulation of synaptic plasticity which plays an important role in learning and memory. It participates in the NMDA receptor signaling pathway interacting with proteins like PSD-95 which is important for synapse maturation and plasticity. Additionally DLG2 is linked to the MAPK signaling pathway which impacts cell growth division and differentiation.

DLG2 has associations with neurological disorders such as schizophrenia and intellectual disabilities. Its interaction with proteins like SHANK3 which are implicated in neuropsychiatric conditions suggests that dysregulation of DLG2 can lead to abnormal synaptic signaling linked to these disorders. Understanding DLG2's function and connections is important for exploring therapeutic targets in these brain disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (PubMed : 26880549). Seems to negatively regulate SRC function in epithelial cells (By similarity).
See full target information Mpp2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 41:111766 PubMed36476872

2022

Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning.

Applications

Unspecified application

Species

Unspecified reactive species

Jens Stepan,Daniel E Heinz,Frederik Dethloff,Thomas Bajaj,Andreas Zellner,Kathrin Hafner,Svenja Wiechmann,Sarah Mackert,Yara Mecdad,Michael Rabenstein,Tim Ebert,Silvia Martinelli,Alexander S Häusl,Maximilian L Pöhlmann,Anke Hermann,Xiao Ma,Hermann Pavenstädt,Mathias V Schmidt,Alexandra Philipsen,Chris W Turck,Jan M Deussing,Bernhard Kuster,Michael C Wehr,Valentin Stein,Joachim Kremerskothen,Carsten T Wotjak,Nils C Gassen

Biological procedures online 24:13 PubMed36117173

2022

Single-cell and WGCNA uncover a prognostic model and potential oncogenes in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ziyang Di,Sicheng Zhou,Gaoran Xu,Lian Ren,Chengxin Li,Zheyu Ding,Kaixin Huang,Leilei Liang,Yihang Yuan

Molecular carcinogenesis 59:1323-1342 PubMed33128289

2020

Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR-942-5p and releasing DLG2 via Hippo-YAP signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Shiquan Li,Guoqiang Yan,Wei Liu,Chenyao Li,Xu Wang

PLoS genetics 15:e1008378 PubMed31479451

2019

NME5 frameshift variant in Alaskan Malamutes with primary ciliary dyskinesia.

Applications

Unspecified application

Species

Unspecified reactive species

Linda Anderegg,Michelle Im Hof Gut,Udo Hetzel,Elizabeth W Howerth,Fabienne Leuthard,Kaisa Kyöstilä,Hannes Lohi,Louise Pettitt,Cathryn Mellersh,Katie M Minor,James R Mickelson,Kevin Batcher,Danika Bannasch,Vidhya Jagannathan,Tosso Leeb
View all publications
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