AB97290

Anti-MPP2/DLG2 antibody

Name: Anti-MPP2/DLG2 antibody (ab97290) | Abcam
Brand: Abcam Limited
SKU: AB97290

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(4 Publications)

Rabbit Polyclonal MPP2/DLG2 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MPP2 aa 100-450.

View Alternative Names

DLG2, MPP2, MAGUK p55 subfamily member 2, Discs large homolog 2, Protein MPP2

2 Images

Supplier Data

Western blot - Anti-MPP2/DLG2 antibody (AB97290)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-MPP2/DLG2 antibody (ab97290) at 1/1000 dilution

All lanes:

Mouse brain tissue lysate at 50 µg

Predicted band size: 65 kDa

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Supplier Data

Western blot - Anti-MPP2/DLG2 antibody (AB97290)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-MPP2/DLG2 antibody (ab97290) at 1/1000 dilution

All lanes:

A549 whole cell lysate at 30 µg

Predicted band size: 65 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human MPP2 aa 100-450. The exact immunogen used to generate this antibody is proprietary information.

Q14168

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MPP2 also known as DLG2 (Discs Large Homolog 2) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. It plays a role in maintaining cell polarity and organizing signal complexes at cell junctions. This protein has a mass of approximately 85 kDa. MPP2/DLG2 expresses mainly in the brain particularly in neuronal cells where it contributes to synaptic transmission and plasticity.

Biological function summary

The DLG2 protein acts as a scaffolding protein that organizes other proteins within the synaptic membrane at excitatory synapses. It is part of the heteromeric complex that includes other synaptic proteins facilitating interactions between NMDA receptors and various signaling molecules. By stabilizing these protein interactions DLG2 influences synaptic strength and cellular communication pathways.

Pathways

DLG2 is involved in the regulation of synaptic plasticity which plays an important role in learning and memory. It participates in the NMDA receptor signaling pathway interacting with proteins like PSD-95 which is important for synapse maturation and plasticity. Additionally DLG2 is linked to the MAPK signaling pathway which impacts cell growth division and differentiation.

DLG2 has associations with neurological disorders such as schizophrenia and intellectual disabilities. Its interaction with proteins like SHANK3 which are implicated in neuropsychiatric conditions suggests that dysregulation of DLG2 can lead to abnormal synaptic signaling linked to these disorders. Understanding DLG2's function and connections is important for exploring therapeutic targets in these brain disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed : 19665017).

See full target information MPP2

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 9: PubMed38889014

2024

Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Li,Muhammad Usman,Ellen Sapp,Yuting Ke,Zejian Wang,Adel Boudi,Marian DiFiglia,Xueyi Li

PLoS biology 20:e3001503 PubMed35312684

2022

The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Bettina Schmerl,Niclas Gimber,Benno Kuropka,Alexander Stumpf,Jakob Rentsch,Stella-Amrei Kunde,Judith von Sivers,Helge Ewers,Dietmar Schmitz,Christian Freund,Jan Schmoranzer,Nils Rademacher,Sarah A Shoichet

Bioscience reports 39: PubMed30808715

2019

gene suppresses intracranial aneurysm formation and rupture through inhibiting the NF-κB signaling pathway mediated inflammatory response.

Applications

Unspecified application

Species

Unspecified reactive species

Xian-Liang Lai,Zhi-Feng Deng,Xin-Gen Zhu,Zhi-Hua Chen

Scientific reports 6:35283 PubMed27756895

2016

MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density.

Applications

WB, ICC/IF

Species

Unspecified reactive species, Unspecified reactive species

Nils Rademacher,Bettina Schmerl,Jennifer A Lardong,Markus C Wahl,Sarah A Shoichet

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-MPP2/DLG2 antibody

Western blot - Anti-MPP2/DLG2 antibody (AB97290)

Western blot - Anti-MPP2/DLG2 antibody (AB97290)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise