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AB76327

Anti-MPZL3 antibody

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(2 Publications)

Mouse Polyclonal MPZL3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MPZL3.

View Alternative Names

UNQ2966/PRO7425, MPZL3, Myelin protein zero-like protein 3

1 Images
Western blot - Anti-MPZL3 antibody (AB76327)
  • WB

Unknown

Western blot - Anti-MPZL3 antibody (AB76327)

All lanes:

Western blot - Anti-MPZL3 antibody (ab76327) at 1/500 dilution

Lane 1:

MPZL3 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Predicted band size: 26 kDa

Observed band size: 26 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MPZL3.

Q6UWV2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MPZL3 also known as Myelin Protein Zero-Like 3 is a significant transmembrane glycoprotein. The molecular weight of MPZL3 is approximately 34 kDa. It is expressed in various tissues with prominent levels in the skin and hair follicles. The protein contains an Ig-like domain which is essential for its interaction with other cell surface proteins mediating cellular adhesion processes.
Biological function summary

The function of MPZL3 involves cell-cell adhesion and differentiation. MPZL3 plays an essential role in maintaining the structural integrity of tissues where it is expressed. Evidence suggests it forms part of larger protein complexes on the cell membrane enabling important signaling pathways. Its expression contributes significantly to the regulation of epidermal homeostasis and possibly keratinocyte maturation integrating external adhesive signals to cellular responses.

Pathways

MPZL3 interacts within the integrin signaling pathway and might influence the epidermal growth factor receptor (EGFR) pathway. These pathways are integral for cellular adhesion migration and proliferation. MPZL3's role aligns with other adhesion-related proteins like integrins and cadherins interacting to modulate cellular responses to the extracellular environment and mediate various intracellular signaling cascades.

MPZL3's misregulation or mutation links to conditions like ichthyosis and potentially scarring alopecia. These disorders highlight the protein's importance in skin differentiation and hair follicle regulation. MPZL3 possibly interacts with proteins like filaggrin in ichthyosis emphasizing its role in maintaining normal skin barrier function. Understanding MPZL3’s interaction network provides insight into the molecular basis of these conditions and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates homophilic cell-cell adhesion.
See full target information MPZL3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 12:901728 PubMed35965540

2022

A systemic pan-cancer analysis of MPZL3 as a potential prognostic biomarker and its correlation with immune infiltration and drug sensitivity in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Renhong Huang,Liangqiang Li,Zheng Wang,Kunwei Shen

Virchows Archiv : an international journal of pathology 465:291-8 PubMed24980157

2014

Absence of caveolin-1 expression in carcinoma-associated fibroblasts of invasive micropapillary carcinoma of the breast predicts poor patient outcome.

Applications

Unspecified application

Species

Unspecified reactive species

Meijing Ren,Fangfang Liu,Yufen Zhu,Yaqing Li,Ronggang Lang,Yu Fan,Feng Gu,Xinmin Zhang,Li Fu
View all publications
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