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AB237537

Anti-MRAP2 antibody

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(1 Publication)

Rabbit Polyclonal MRAP2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRAP2 aa 50 to C-terminus.

View Alternative Names

C6orf117, MRAP2, Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRAP2 antibody (AB237537)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRAP2 antibody (AB237537)

Paraffin-embedded human brain tissue stained for MRAP2 with ab237537 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRAP2 antibody (AB237537)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRAP2 antibody (AB237537)

Paraffin-embedded human lung tissue stained for MRAP2 with ab237537 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-MRAP2 antibody (AB237537)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MRAP2 antibody (AB237537)

U-251 MG (human brain glioma cell line) cells stained for MRAP2 (green) using ab237537 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-MRAP2 antibody (AB237537)
  • WB

Supplier Data

Western blot - Anti-MRAP2 antibody (AB237537)

All lanes:

Western blot - Anti-MRAP2 antibody (ab237537) at 1/1000 dilution

Lane 1:

Mouse brain tissue lysate

Lane 2:

Mouse kidney tissue lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 24 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MRAP2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96G30

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRAP2 also known as Melanocortin-2 Receptor Accessory Protein 2 is a protein that modulates the activity of melanocortin receptors primarily MC4R. It has a molecular mass of about 16 kDa and is expressed in several regions of the brain including the hypothalamus. MRAP2 plays a role in supporting the function of these receptors by facilitating their trafficking and increasing their functionality on the cell surface.
Biological function summary

MRAP2 interacts with the melanocortin system which involves energy balance and appetite regulation. It forms a complex with melanocortin receptors especially MC4R and to some extent MC3R influencing signaling pathways that control food intake. This system is fundamental in the regulation of metabolism reflecting the importance of MRAP2 in maintaining energy homeostasis in organisms.

Pathways

MRAP2 operates within the melanocortin pathway interacting closely with the leptin signaling pathway which governs energy expenditure and appetite. MRAP2 supports the function of MC4R which in turn relates to the regulation of adenylyl cyclase activity affecting cAMP levels. MC4R is also involved in the leptin-melanocortin pathway showing how MRAP2 assists in linking energy intake and energy expenditure processes.

MRAP2 impacts conditions like obesity and metabolic syndrome due to its influence on energy balance and metabolic processes. Dysfunctional MRAP2 activity has associations with leptin receptor pathways which can lead to altered appetite regulation and weight gain. Additionally MRAP2 has links with genetic conditions involving MC4R that contribute to weight disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R : competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo.
See full target information MRAP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:801687 PubMed35096829

2022

Identification and Validation of Key Genes of Differential Correlations in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tingna Chen,Qiuming He,Zhenxian Xiang,Rongzhang Dou,Bin Xiong
View all publications
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