Anti-MRF-1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

MRF-1 commonly known as Muscle Ring Finger-1 is a protein that functions as an E3 ubiquitin ligase. It plays a role in tagging proteins for degradation by the proteasome. This protein has a molecular mass of approximately 40 kDa. MRF-1 is mainly expressed in skeletal muscle tissue though it is also found in cardiac muscle. Researchers have identified its involvement in muscle atrophy making it a target of interest in muscle biology studies.

Biological function summary

The protein contributes to muscle protein turnover and homeostasis. It forms part of a complex that includes other ubiquitin ligases like MuRF2 and atrogin-1. MRF-1 facilitates the modification of target proteins through ubiquitination which marks them for destruction. This role is important during the muscle-wasting process where the turnover of muscle proteins is heightened. As a result MRF-1 assists in maintaining muscle structure and function under conditions that promote catabolism.

Pathways

MRF-1 is significantly involved in pathways regulating muscle protein degradation including the ubiquitin-proteasome pathway. It associates with proteins like myosin heavy chain and tropomyosin linking it to the cellular processes governing muscle contraction and structure. MRF-1 often works alongside signaling pathways like the NF-kB pathway emphasizing its role in response to inflammatory signals and stress-inducing conditions.

Associated diseases and disorders

MRF-1 is particularly relevant to conditions such as muscle atrophy and cachexia. It shows elevated expression in atrophic muscles marking it as a potential contributor to muscle-wasting disorders. The protein also connects with atrogin-1 another key player in muscle degradation indicating a collaborative function in such conditions. The study of MRF-1 in these contexts sheds light on therapeutic approaches that may mitigate muscle loss offering hope for affected individuals.