Anti-MRG15 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

MRG15 also known as MORF Related Gene 15 is a protein weighing approximately 34 kDa. This protein plays a significant role in chromatin remodeling and gene expression. Researchers have identified MRG15 in various tissues with a notable expression in neural and skeletal muscle tissues. The protein engages actively in the cellular processes related to chromatin and gene regulation which are essential for maintaining normal cellular function.

Biological function summary

MRG15 integrates into several protein complexes including the histone acetyltransferase complex where it interacts with other components to regulate transcription. The structure of MRG15 enables it to bind to methylated histones facilitating histone modification and affecting gene expression levels. Researchers observe its impact on the modulation of DNA repair and replication through its participation in these complexes.

Pathways

MRG15 operates mostly within the DNA damage repair and cell cycle progression pathways. It forms critical interactions with proteins such as ASF1 and TIP60 which influence histone acetylation and chromatin structure. These tasks are essential for the correct execution of the repair mechanisms and maintenance of genomic stability.

Associated diseases and disorders

Researchers associate MRG15 with neurodegenerative diseases and certain cancer types. The protein's close relationship with BRCA1 and p300 which are also implicated in these conditions indicates its participation in tumorigenesis and neural degeneration processes. Dysfunctional MRG15 activity can lead to impaired DNA repair contributing to disease pathogenesis in these disorders.