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AB188740

Anti-MRGPRX4 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal MRGPRX4 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MRGPRX4.

View Alternative Names

MRGX4, SNSR5, SNSR6, MRGPRX4, Mas-related G-protein coupled receptor member X4, Sensory neuron-specific G-protein coupled receptor 5/6

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGPRX4 antibody - C-terminal (AB188740)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGPRX4 antibody - C-terminal (AB188740)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Skin, Melanoma tissue after heat-induced antigen retrieval labeling MRGPRX4 with ab188740 at 16 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGPRX4 antibody - C-terminal (AB188740)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGPRX4 antibody - C-terminal (AB188740)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spinal cord, dorsal root ganglion tissue labeling MRGPRX4 with ab188740 at 16 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGPRX4 antibody - C-terminal (AB188740)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGPRX4 antibody - C-terminal (AB188740)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Brain, Glioblastoma tissue labeling MRGPRX4 with ab188740 at 16 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGPRX4 antibody - C-terminal (AB188740)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGPRX4 antibody - C-terminal (AB188740)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Lung, Non-Small Cell Carcinoma tissue labeling MRGPRX4 with ab188740 at 16 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MRGPRX4. The exact immunogen used to generate this antibody is proprietary information.

Q96LA9

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MRGPRX3 (67%), MRGPRX1 (67%), ALMS1 (44%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3-16 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRGPRX4 also known as Mas-related G-protein coupled receptor member X4 is a target involved in several physiological processes. This G-protein coupled receptor (GPCR) has a molecular weight that approximately ranges around 37 kDa. It is part of a larger family of GPCRs and localizes mainly in human tissues predominantly within the brain and skin. MRGPRX4 contributes to signal transduction upon activation by endogenous ligands leading to diverse cellular responses.
Biological function summary

This receptor plays a role in sensory perception and possibly in the detection of noxious stimuli. It interacts within a complex network of receptors involved in signaling pathways related to sensory responses. MRGPRX4 is thought to be significant in modulating physiological responses to external stimuli such as pruritogenic compounds. The receptor likely forms functional complexes with other GPCRs facilitating coordinated signaling events that are essential for adaptive responses.

Pathways

MRGPRX4 is implicated in nociceptive signaling and pruritus pathways. It shares close relationships with other MRGPR family members involved in these pathways. Through these interactions MRGPRX4 influences the transmission of signals that alert the organism to harmful stimuli coordinating with related proteins to mediate perception and reaction. It facilitates the conversion of external chemical stimuli into intracellular actions leading to appropriate organismal responses.

MRGPRX4 shows a connection with chronic itch conditions and neuropathic pain. Abnormalities in the function or expression of MRGPRX4 might contribute to these disorders. The receptor associates with other sensory receptors and ion channels such as TRPV1 within these pathologic contexts. Understanding the role of MRGPRX4 in these conditions provides potential avenues for therapeutic interventions targeting its signaling mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
See full target information MRGPRX4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 6:35205 PubMed27748416

2016

MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection.

Applications

Unspecified application

Species

Unspecified reactive species

Qin-Qin He,Liu-Lin Xiong,Fei Liu,Xiang He,Guo-Ying Feng,Fei-Fei Shang,Qing-Jie Xia,You-Cui Wang,De-Lu Qiu,Chao-Zhi Luo,Jia Liu,Ting-Hua Wang
View all publications
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