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AB77519

Anti-MRGX1 antibody

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(1 Publication)

Rabbit Polyclonal MRGX1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MRGPRX1.

View Alternative Names

MRGX1, SNSR3, SNSR4, MRGPRX1, Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4

1 Images
Western blot - Anti-MRGX1 antibody (AB77519)
  • WB

Unknown

Western blot - Anti-MRGX1 antibody (AB77519)

All lanes:

Western blot - Anti-MRGX1 antibody (ab77519) at 1/500 dilution

Lane 1:

Extracts from MCF-7 cells at 5 µg

Lane 2:

Extracts from MCF-7 cells at 5 µg with immunising peptide

Predicted band size: 36 kDa

Observed band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human MRGPRX1. The exact immunogen used to generate this antibody is proprietary information.

Q96LB2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRGX1 also known as Mas-related G-protein coupled receptor X1 is a protein encoded by the MRGX1 gene. It has a mass of approximately 37 kDa. MRGX1 is primarily expressed in the dorsal root ganglion neurons and plays a significant role in nociception which is the sensory perception of pain. This receptor is involved in modulating pain signals and contributes to sensory neuron regulation. MRGX1 is less expressed in other tissues which indicates a specialized function within the peripheral nervous system.
Biological function summary

MRGX1 is involved in pain sensation and is not part of a larger protein complex. Its role is important in pain perception as it modulates the response of sensory neurons to painful stimuli. MRGX1 affects the response threshold for pain contributing to the transmission of both acute and chronic pain signals. The receptor potentially interacts with various ligands to influence pain pathways suggesting that it could be an attractive target for pain management therapies.

Pathways

MRGX1 engages in the G-protein coupled receptor (GPCR) signaling pathway. It plays a significant role by interacting with signaling molecules that affect neuronal excitability and pain perception. MRGX1 functions alongside proteins such as BAM 8-22 a peptide known to activate this receptor and BAM 8 another peptide associated with MRGX1 signaling. These interactions facilitate a complex regulatory mechanism within the GPCR pathway influencing downstream effects on pain modulation.

MRGX1 relates to neuropathic pain and chronic pain conditions. Abnormal MRGX1 expression or function has connections to these pain conditions making it a potential target for therapeutic development. The receptor's interaction with proteins such as BAM 8-22 is significant in the context of pain management as modulating these interactions could offer relief for patients suffering from pain disorders. Understanding the exact role of MRGX1 in these conditions can guide the development of targeted treatments to ameliorate pain symptoms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22) (PubMed : 26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
See full target information MRGPRX1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy oncolytics 17:384-393 PubMed32405536

2020

G Protein-Coupled Receptor GPR87 Promotes the Expansion of PDA Stem Cells through Activating JAK2/STAT3.

Applications

Unspecified application

Species

Unspecified reactive species

Jianxin Jiang,Chao Yu,Xingjun Guo,Hao Zhang,She Tian,Kun Cai,Zhiwei He,Chengyi Sun
View all publications
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