AB140863

Anti-MRGX3 antibody - Extracellular domain

Name: Anti-MRGX3 antibody - Extracellular domain (ab140863) | Abcam
Brand: Abcam Limited
SKU: AB140863

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(1 Publication)

Rabbit Polyclonal MRGX3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MRGPRX3.

View Alternative Names

MRGX3, SNSR1, SNSR2, MRGPRX3, Mas-related G-protein coupled receptor member X3, Sensory neuron-specific G-protein coupled receptor 1/2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (AB140863)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (AB140863)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Brain Cerebellum (Purkinje Neurons) tissue labelling MRGX3 with ab140863 at 21 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MRGPRX3. The exact immunogen used to generate this antibody is proprietary information.

Q96LB0

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MRGPRX4 (59%), LRRK2 (53%), CACNB4 (47%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "21 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRGX3 also known as MAS-related G protein-coupled receptor member X3 is a G protein-coupled receptor primarily involved in cell signaling. It has a molecular mass of approximately 45 kDa. MRGX3 predominantly expresses in the dorsal root ganglia and a subset of sensory neurons. As a receptor MRGX3 binds to specific ligands and activates intracellular G proteins leading to downstream signaling cascades.

Biological function summary

The receptor influences pain sensation and modulation pathways. It does this by interacting with various ligands to modulate neuronal excitability. MRGX3 does not appear to form part of a larger receptor complex but acts within the framework of peripheral nervous system signaling. Its presence in sensory neurons suggests an essential role in responding to environmental stimuli and possibly modulating inflammatory responses.

Pathways

MRGX3 takes part in the pain regulation and sensory perception pathways. It interacts with other proteins like TRPV1 which is involved in the heat pain pathway and modulates pain sensation. While MRGX3's precise place in the signaling pathway is not entirely understood it is clear that it influences signal transduction through G protein-dependent mechanisms relevant for pain and sensory functions.

MRGX3 connects to neuropathic pain and chronic inflammation-related disorders. Alterations or dysregulation of MRGX3 function can contribute to exacerbated pain states. Studies suggest an interaction with proteins such as GPR183 linking MRGX3 to the development of chronic pain disorders though research is ongoing to fully elucidate these connections.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

See full target information MRGPRX3

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 10:e0117581 PubMed25807145

2015

Discovery of molecular markers to discriminate corneal endothelial cells in the human body.

Applications

Unspecified application

Species

Unspecified reactive species

Masahito Yoshihara,Hiroko Ohmiya,Susumu Hara,Satoshi Kawasaki,Yoshihide Hayashizaki,Masayoshi Itoh,Hideya Kawaji,Motokazu Tsujikawa,Kohji Nishida

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MRGX3 antibody - Extracellular domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (AB140863)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise