Anti-MRP1 antibody [MRPm5]
4
(3 Reviews)
|
(67 Publications)
Mouse Monoclonal MRP1 antibody. Suitable for Flow Cyt, WB, IHC-P, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 67 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCC1 aa 950 to C-terminus.
View Alternative Names
MRP, MRP1, ABCC1, Multidrug resistance-associated protein 1, ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, LTC4 transporter
Reactivity data
Properties and storage information
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Aliquoting information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This protein functions as an important determinant of multidrug resistance in cancer treatment. MRP1 can form part of a larger protein complex that includes other transporters like MRP2. Through its activity MRP1 protects tissues from toxic substances by transporting them out of the cell. Its role in transporting glutathione-conjugated compounds highlights its importance in cellular defense mechanisms against oxidative stress and xenobiotics.
Pathways
MRP1 participates in the glutathione metabolism and the xenobiotic efflux pathways. Both pathways involve cellular detoxification and the accumulation of anomalies can cause harmful effects in the body. MRP1 works with proteins such as GSTP1 which conjugates toxic substances with glutathione preparing them for export by MRP1. This coordination ensures efficient detoxification and protection of cells from damage.
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Target data
Publications (67)
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Basic and clinical neuroscience 14:615-630 PubMed38628830
2024
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Fluids and barriers of the CNS 21:5 PubMed38200564
2024
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Nature communications 14:5709 PubMed37726279
2023
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Cancers 15: PubMed37627134
2023
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Journal of Cancer 14:1515-1530 PubMed37325046
2023
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Cancer science 114:3027-3040 PubMed37190912
2023
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ALTEX 40:103-116 PubMed35648122
2022
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ALTEX 40:34–52 PubMed35575642
2022
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ALTEX 40:61-82 PubMed35536601
2022
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Nature communications 13:2083 PubMed35440587
2022
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Product promise
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