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AB203397

Anti-MRP2 antibody

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(21 Publications)

Rabbit Polyclonal MRP2 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 21 publications. Immunogen corresponding to Synthetic Peptide within Human ABCC2 aa 450-550 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CMOAT, CMOAT1, CMRP, MRP2, ABCC2, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, Multidrug resistance-associated protein 2

2 Images
Western blot - Anti-MRP2 antibody (AB203397)
  • WB

Supplier Data

Western blot - Anti-MRP2 antibody (AB203397)

All lanes:

Western blot - Anti-MRP2 antibody (ab203397)

Predicted band size: 174 kDa

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Western blot - Anti-MRP2 antibody (AB203397)
  • WB

Supplier Data

Western blot - Anti-MRP2 antibody (AB203397)

All lanes:

Western blot - Anti-MRP2 antibody (ab203397)

Predicted band size: 174 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ABCC2 aa 450-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q92887

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRP2 also known as ABCC2 or MRP-2 transporter is an ATP-binding cassette transporter. This protein with a molecular mass of about 190 kDa is widely expressed in tissues such as the liver kidney and intestine. MRP2 plays a role in drug and metabolite transport moving various organic anions across cellular membranes. It locates to the canalicular membrane of hepatocytes where it functions in secreting conjugated bilirubin and drugs into bile.
Biological function summary

MRP2 contributes to cellular detoxification processes. It does not form part of a larger protein complex but works as an independent entity. MRP2 protein actively transports conjugated substances out of cells protecting tissues from potential damage from toxins drugs and other organic anions. This transporter mediates the excretion of glucuronide sulfate and glutathione conjugates playing an important role in phase III of drug metabolism.

Pathways

MRP2 transporter is integral to xenobiotic metabolism. It interconnects with the conjugation pathways that prepare compounds for excretion. The pathway functions with cytochrome P450 enzymes and other related transport proteins like MDR1 facilitating the secretion of detoxified metabolites. MRP2 activity influences pharmacokinetics and pharmacodynamics by modulating drug disposition and excretion.

MRP2 is associated with Dubin-Johnson syndrome and cholestasis. Dubin-Johnson syndrome arises from mutations in the ABCC2 gene leading to defective bilirubin excretion and jaundice. Cholestasis involves impaired bile excretion where MRP2 and possibly related proteins like BSEP play roles in bile salt export. Understanding MRP2 functioning aids in assessing risk and treatment strategies for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed : 10220572, PubMed : 10421658, PubMed : 11500505, PubMed : 16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed : 10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed : 11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed : 16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed : 10220572, PubMed : 11500505, PubMed : 12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed : 10220572, PubMed : 11500505).
See full target information ABCC2
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Publications (21)

Recent publications for all applications. Explore the full list and refine your search

BMC neuroscience 24:37 PubMed37474902

2023

Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Bai,Wen Mi,Xiaoyin Meng,Beibei Dong,Yi Jiang,Yuechun Lu,Yonghao Yu

Evidence-based complementary and alternative medicine : eCAM 2022:2481654 PubMed36285162

2022

Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models.

Applications

Unspecified application

Species

Unspecified reactive species

Qun Wang,Yonglin Wang,Wen Liu,Dingyan Lu,Yang Jin,Nian Tang,Ya Shi,Zipeng Gong,Weiyi Tian,Ting Liu

Evidence-based complementary and alternative medicine : eCAM 2020:2696432 PubMed33273950

2020

Green Tea Polyphenols Protect against Acetaminophen-Induced Liver Injury by Regulating the Drug Metabolizing Enzymes and Transporters.

Applications

Unspecified application

Species

Unspecified reactive species

Le Lv,Chenshu Xu,Xiaoye Mo,Hai-Yan Sun,Huichang Bi

Pharmaceutical research 37:158 PubMed32743772

2020

Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Zhou,Bin Du,Min Kan,Shang Chen,Bo-Hao Tang,Ai-Qing Nie,Pan-Pan Ye,Hai-Yan Shi,Guo-Xiang Hao,Xiu-Li Guo,Qiu-Ju Han,Yi Zheng,Wei Zhao

Transplantation direct 6:e584 PubMed32766432

2020

Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Joohyun Kim,Catherine E Hagen,Suresh N Kumar,Jong-In Park,Michael A Zimmerman,Johnny C Hong

Phytomedicine : international journal of phytother 76:153257 PubMed32534360

2020

Ethyl acetate extract of herpetospermum pedunculosum alleviates α-naphthylisothiocyanate-induced cholestasis by activating the farnesoid x receptor and suppressing oxidative stress and inflammation in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaodong Wei,Xudong Fan,Zhiying Feng,Yingxiong Ma,Xiaozhong Lan,Min Chen

Cancer biotherapy & radiopharmaceuticals 35:741-752 PubMed32407172

2020

Long Noncoding RNA Plasmacytoma Variant Translocation 1 Regulates Cisplatin Resistance via miR-3619-5p/TBL1XR1 Axis in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Wu,Yu Hu,Yongjie Ning,Aili Zhao,Guangwei Zhang,Lin Yan

Oxidative medicine and cellular longevity 2020:9820168 PubMed32377314

2020

Renoprotective Effects of a New Free Radical Scavenger, XH-003, against Cisplatin-Induced Nephrotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Ya-Hong Liu,Kui Li,Hong-Qi Tian

Molecular therapy. Nucleic acids 19:168-178 PubMed31838274

2019

LINC01234/MicroRNA-31-5p/MAGEA3 Axis Mediates the Proliferation and Chemoresistance of Hepatocellular Carcinoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yunhao Chen,Hui Zhao,Haibo Li,Xiao Feng,Hui Tang,Chunhui Qiu,Jianwen Zhang,Binsheng Fu

British journal of pharmacology 176:4558-4573 PubMed31378931

2019

Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Jiangnan Zhang,Ran Bi,Qiang Meng,Changyuan Wang,Xiaokui Huo,Zhihao Liu,Chong Wang,Pengyuan Sun,Huijun Sun,Xiaodong Ma,Jingjing Wu,Kexin Liu
View all publications
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