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AB167564

Anti-MRP6/ARA antibody

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Mouse Polyclonal MRP6/ARA antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ABCC6.

View Alternative Names

ARA, MRP6, ABCC6, ATP-binding cassette sub-family C member 6, Anthracycline resistance-associated protein, Multi-specific organic anion transporter E, Multidrug resistance-associated protein 6, MOAT-E

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ABCC6.

O95255

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The human multidrug resistance-associated protein 6 (MRP6) also known as ATP-binding cassette sub-family C member 6 (ABCC6) or ARA serves as an important transporter protein. MRP6 weighs approximately 165 kDa and spans the cell membrane to transport various molecules out of the cell. This transport protein expresses highly in the liver and kidney tissues. By exporting certain substrates MRP6 plays an important role in managing cellular environments and protecting tissues from harmful substances.
Biological function summary

MRP6 contributes to the cellular management of organic anions and xenobiotics. It operates as part of the ATP-binding cassette transporters family using energy derived from ATP hydrolysis to drive the transport process. In this role MRP6 can influence the body's detoxification system and help in the excretion of unwanted and potentially toxic compounds. This activity is critical for maintaining homeostasis and protecting cells from damage due to various compounds.

Pathways

Research shows MRP6 operates in the broader context of transporter-mediated drug resistance pathways. Interestingly MRP6 interacts with other proteins such as MRP1 and MRP2 which share similar functions within these pathways. The activity of MRP6 in the extrusion of xenobiotics contributes to a multi-faceted defense mechanism often examined under the scope of chemotherapeutic resistance and transport of physiological metabolites.

Studies highlight MRP6's association with pseudoxanthoma elasticum (PXE) a rare genetic disease characterized by mineralization of elastic fibers in tissues. Mutations in the encoding gene for MRP6 disrupt its functional capacity and lead to disease pathology. Additionally researchers explore the relationship between MRP6 activity and calcification disorders due to its roles in substrate transport and mineral metabolism. MRP6's connection with proteins like ABCC1 emphasizes potential interactions with wider metabolic pathways contributing to disease manifestations.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed : 11880368, PubMed : 12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed : 12414644).. Isoform 1. Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis.. Isoform 2. Inhibits TNF-mediated apoptosis through blocking one or more caspases.
See full target information ABCC6
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