Anti-MRPL1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The MRPL1 protein also known as Mitochondrial Ribosomal Protein L1 is an essential component of the mitochondrial ribosome. It weighs approximately 34.1 kDa and plays a critical mechanical role in the synthesis of proteins within mitochondria. MRPL1 is expressed in various tissues with high metabolic activity particularly in the liver muscle and brain reflecting its importance in these energy-demanding areas.

Biological function summary

MRPL1 contributes to mitochondrial protein synthesis by being part of the mitochondrial large ribosomal subunit. It is one of the components that build the ribosome's structure enabling the translation of mitochondrial-encoded proteins. This integration into the ribosomal complex facilitates the accurate translation of mRNA which is necessary for proper mitochondrial function and energy production.

Pathways

MRPL1 functions in pathways related to mitochondrial translation and energy metabolism. It plays a part in the mitochondrial translation pathway a critical component for cellular energy production through oxidative phosphorylation. This pathway largely involves interactions with proteins such as MRPS22 which is part of the small subunit aiding in the synthesis of proteins important for the electron transport chain.

Associated diseases and disorders

Altered MRPL1 function is associated with mitochondrial diseases and metabolic disorders. Mutations or defects in MRPL1 can lead to conditions like cardiomyopathy and MELAS syndrome (Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like episodes). In these diseases the relationship between MRPL1 and the malfunctioning of mitochondrial-encoded proteins is evident and it interacts with other mRNAs translated in mitochondria impacting cellular energy balance.