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AB190232

Anti-MRPL13 antibody

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(4 Publications)

Rabbit Polyclonal MRPL13 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MRPL13 aa 100 to C-terminus.

View Alternative Names

Large ribosomal subunit protein uL13m, L13mt, MRP-L13, MRPL13

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL13 antibody (AB190232)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL13 antibody (AB190232)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung tissue labeling MRPL13 with ab190232 at 10 μg/ml.

Western blot - Anti-MRPL13 antibody (AB190232)
  • WB

Supplier Data

Western blot - Anti-MRPL13 antibody (AB190232)

All lanes:

Western blot - Anti-MRPL13 antibody (ab190232) at 1/500 dilution

Lane 1:

A549 cell extracts

Lane 2:

A549 cell extracts with synthesized peptide.

Predicted band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human MRPL13 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BYD1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRPL13 also known as mitochondrial ribosomal protein L13 plays an important role in mitochondrial protein synthesis. It is a component of the mitochondrial ribosome large subunit (39S). The molecular mass of MRPL13 is approximately 18 kilodaltons. This protein is primarily expressed in tissues with high energy demands such as skeletal muscle heart and brain. MRPL13 functions within the mitochondrial matrix contributing to the assembly and stability of the ribosome.
Biological function summary

MRPL13 facilitates the process of mitochondrial translation which is essential for the production of proteins encoded by the mitochondrial genome. MRPL13 forms part of the 39S subunit of the mitochondrial ribosome working alongside other ribosomal proteins to translate mitochondrial mRNAs. This activity is critical for the maintenance of mitochondrial function as mitochondria rely on their own protein synthesis machinery to support cellular energy production.

Pathways

MRPL13 plays a vital role in the oxidative phosphorylation pathway which is key for ATP production in cells. This pathway involves numerous proteins including cytochrome c oxidase and ATP synthase which work together to generate ATP from ADP. MRPL13 assists in the synthesis of mitochondrial components of oxidative phosphorylation ensuring efficient energy production. Its role in translation further connects MRPL13 to the regulation of mitochondrial biogenesis and energy metabolism within the cell.

MRPL13 has been linked to mitochondrial dysfunction and syndromes characterized by impaired energy metabolism such as mitochondrial myopathy and Leigh syndrome. Abnormalities in MRPL13 affect the assembly and function of the mitochondrial ribosome disrupting ATP production and leading to clinical symptoms. This protein might interact with other mitochondrial ribosomal proteins like MRPS22 to influence disease progression. Understanding MRPL13's involvement in these conditions can aid in developing therapeutic strategies targeting mitochondrial bioenergetics.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MRPL13
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:13435 PubMed40251302

2025

SLC25A19 is a key prognostic marker for hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Chen,Xiaomei Ying,Jiaheng Xie,Hong Liu,Wen Liu

Gene 932:148908 PubMed39218414

2024

MRPL13 is a metastatic and prognostic marker of breast cancer: A silico analysis accompanied with experimental validation.

Applications

Unspecified application

Species

Unspecified reactive species

Pei Dai,Yan'an Chen,Xiao Zhang,Long Liu,Zhenbo Cheng

Aging 15:10640-10680 PubMed37827692

2023

Multi-omics analysis of MRPL-13 as a tumor-promoting marker from pan-cancer to lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xugang Zhong,Zeju He,Yong Fan,Li Yin,Zheping Hong,Yu Tong,Qing Bi,Senbo Zhu

Cancer management and research 13:2009-2024 PubMed33658859

2021

MRPL13 Promotes Tumor Cell Proliferation, Migration and EMT Process in Breast Cancer Through the PI3K-AKT-mTOR Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Miaomiao Cai,Hanning Li,Runfa Chen,Xiang Zhou
View all publications
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