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AB138281

Anti-MRPL14 antibody

2

(1 Review)

|

(1 Publication)

Rabbit Polyclonal MRPL14 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MRPL14.

View Alternative Names

MRPL32, RPML32, MRPL14, Large ribosomal subunit protein uL14m, L14mt, MRP-L14, L32mt, MRP-L32

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MRPL14. The exact immunogen used to generate this antibody is proprietary information.

Q6P1L8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab138281 was affinity purified from rabbit antiserum by immunogenic peptide affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRPL14 also known as Mitochondrial Ribosomal Protein L14 plays a mechanical role in the mitochondrial ribosome as part of the large 39S subunit. The protein has a molecular mass of approximately 16 kDa. MRPL14 is expressed in the mitochondria and aids in protein synthesis within this organelle. This protein is essential for the proper assembly and stability of the mitochondrial ribosome which is critical for mitochondrial translation.
Biological function summary

MRPL14 is vital for the function of the mitochondrial translation complex helping to decode mitochondrial-encoded proteins. It may interact with other ribosomal proteins within the 39S subunit to ensure efficient protein synthesis. The mitochondrial ribosome including MRPL14 is responsible for translating mRNA that is encoded by mitochondrial DNA which is important for producing components necessary for cellular energy production.

Pathways

The MRPL14 protein plays an important role in processes such as oxidative phosphorylation and the mitochondrial biogenesis pathway. It is closely linked with other mitochondrial ribosomal proteins like MRPL3 within these pathways. These proteins together contribute to the synthesis of essential components of the electron transport chain which is directly involved in ATP production a critical energy source for the cell.

MRPL14 has been associated with mitochondrial dysfunctions that can lead to conditions such as mitochondrial myopathy and Leigh syndrome. These disorders often result from defects in mitochondrial protein synthesis where MRPL14 interacts with other mitochondrial ribosomal proteins like MRPS22. Abnormalities in the function of MRPL14 may disrupt the proper energy production in cells contributing to the pathophysiology of these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).
See full target information MRPL14
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 11:e0156081 PubMed27224062

2016

SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Rannar Airik,Markus Schueler,Merlin Airik,Jang Cho,Kelsey A Ulanowicz,Jonathan D Porath,Toby W Hurd,Simon Bekker-Jensen,Jacob M Schrøder,Jens S Andersen,Friedhelm Hildebrandt
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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