Anti-MRPL30 antibody [EPR12502] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

MRPL30 also known as Mitochondrial Ribosomal Protein L30 is a component of the mitochondrial ribosome. This protein has a molecular mass of approximately 42.7 kDa and is encoded by the MRPL30 gene. Expression of MRPL30 occurs mainly in mitochondria across various tissues where it is involved in protein synthesis within the mitochondria. Its presence is important for the maintenance of mitochondrial function as it helps translate mitochondrial RNA into essential proteins.

Biological function summary

MRPL30 contributes to mitochondrial protein synthesis as a part of the large subunit in the mitochondrial ribosome complex. This complex differs from cytoplasmic ribosomes due to its unique protein-to-rRNA composition reflecting its specific role within mitochondria. MRPL30's involvement in the formation of the ribosomal subunit supports the production of proteins necessary for oxidative phosphorylation. This synthesis is essential for energy production and normal cellular metabolism.

Pathways

The functioning of MRPL30 integrates into mitochondrial protein synthesis and oxidative phosphorylation pathways. The protein ensures the efficient translation of mitochondrial-encoded genes important for ATP production through oxidative phosphorylation. It interacts with other ribosomal proteins such as MRPL28 and MRPL44 important for the assembly and function of the mitochondrial ribosome and thereby sustaining cellular energy demands.

Associated diseases and disorders

Alterations in MRPL30 expression or function can link to mitochondrial dysfunction-related disorders including mitochondrial diseases. These diseases often result from impaired ATP production due to defective oxidative phosphorylation. Research also associates MRPL30 with neurodegenerative diseases as mitochondria play an important role in neuronal function. Its interaction with other mitochondrial ribosomal proteins like MRPS12 can affect mitochondrial translation stability contributing to the pathophysiology of such disorders.