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AB224467

Anti-MRPL37 antibody

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(1 Publication)

Rabbit Polyclonal MRPL37 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL37 aa 100-200.

View Alternative Names

MRPL2, RPML2, HSPC235, MRPL37, Large ribosomal subunit protein mL37, L2mt, MRP-L2, L37mt, MRP-L37

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-MRPL37 antibody (AB224467)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MRPL37 antibody (AB224467)

PFA-fixed/Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for MRPL37 (green) using ab224467 (4 μg/ml) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL37 antibody (AB224467)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL37 antibody (AB224467)

Paraffin embedded human fallopian tube tissue stained for MRPL37 with ab224467 (1/20 dilution) in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MRPL37 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9BZE1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target MRPL37 also known as Mitochondrial Ribosomal Protein L37 plays a role in protein synthesis within the mitochondria. With a molecular mass of approximately 47 kDa MRPL37 is a component of the large subunit in mitochondrial ribosomes. It is expressed in a range of tissues reflecting its essential role in cellular respiration and metabolism. This protein localizes to the mitochondrial matrix hinting at its critical function within the organelle's unique environment.
Biological function summary

MRPL37 helps in forming mitochondrial ribosomes which consist of a conglomerate of proteins and rRNA unique from their cytoplasmic counterparts. It is a component of the 39S large mitochondrial ribosomal subunit. MRPL37’s integration into this complex highlights its role in the translation of mitochondrial DNA-encoded proteins. These proteins are primarily integral to the oxidative phosphorylation pathway linking MRPL37 to energy production within cells.

Pathways

MRPL37 participates in mitochondrial translation and is essential for the oxidative phosphorylation pathway which is important for ATP synthesis. This pathway is a central component of cellular energy production involving related proteins such as ATP synthase and cytochrome c oxidase. In this context MRPL37 ensures the synthesis of key mitochondrial proteins required for the electron transport chain's proper operation.

Deficiencies or mutations in MRPL37 correlate with mitochondrial disorders often presenting as myopathies or neurodegenerative diseases due to impaired energy production. Additionally there is a link between MRPL37 and Leigh syndrome a severe neurological disorder. Such associations underline the necessity of proper mitochondrial function with MRPL37 interacting with other mitochondrial-related proteins such as NDUFAF2 in disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MRPL37
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e05545 PubMed40548473

2025

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet-Induced Obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Yang,Bin Huang,Baixue Sha,Danni Gao,Yimeng Qin,Ziyi Li,Xi Chen,Yinuo Jin,Yi Pan,Yanfeng Zhang,Yumeng Shen,Yu Liu,Liang Jin,Fangfang Zhang
View all publications
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Product promise

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