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AB224341

Anti-MRPS22 antibody

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(1 Publication)

Rabbit Polyclonal MRPS22 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRPS22 aa 50-200.

View Alternative Names

C3orf5, RPMS22, GK002, MRPS22, Small ribosomal subunit protein mS22, MRP-S22, S22mt

4 Images
Immunocytochemistry/ Immunofluorescence - Anti-MRPS22 antibody (AB224341)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MRPS22 antibody (AB224341)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for MRPS22 (green) using ab224341 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPS22 antibody (AB224341)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPS22 antibody (AB224341)

Paraffin-embedded human lymph node tissue stained for MRPS22 using ab224341 at 1/200 dilution in immunohistochemical analysis.

Western blot - Anti-MRPS22 antibody (AB224341)
  • WB

Supplier Data

Western blot - Anti-MRPS22 antibody (AB224341)

All lanes:

Western blot - Anti-MRPS22 antibody (ab224341) at 1/100 dilution

Lane 1:

RT4 (human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG sp (human brain glioma cell line) cell lysate

Predicted band size: 41 kDa

false

Western blot - Anti-MRPS22 antibody (AB224341)
  • WB

Supplier Data

Western blot - Anti-MRPS22 antibody (AB224341)

All lanes:

Western blot - Anti-MRPS22 antibody (ab224341) at 1/100 dilution

Lane 1:

NIH/3T3 (mouse embryo fibroblast cell line) cell lysate

Lane 2:

NBT-II cell lysate

Predicted band size: 41 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MRPS22 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

P82650

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MRPS22 protein also known as mitochondrial ribosomal protein S22 plays a significant role in mitochondrial protein synthesis. The protein has a mass of approximately 44 kDa and is a component of the small subunit of the mitochondrial ribosome. MRPS22 expresses in tissues with high energy demands such as the heart muscle and brain indicating its importance in cellular energy production.
Biological function summary

MRPS22 contributes to the formation of the mitochondrial 28S ribosomal subunit forming part of the mitochondrial ribosome complex. This complex is essential for translating mitochondrial mRNA encoding proteins necessary for mitochondrial respiratory function. Therefore MRPS22 maintains the mitochondrial translation machinery's efficiency ensuring effective protein synthesis vital to cellular energy production.

Pathways

MRPS22 is involved in the mitochondrial translation pathway which is essential for the production of proteins necessary for oxidative phosphorylation. MRPS22 interacts closely with other mitochondrial ribosomal proteins like MRPL12 ensuring coordinated protein synthesis. Through the oxidative phosphorylation pathway MRPS22 supports energy production critical for numerous cellular processes.

Defective MRPS22 function relates to conditions like mitochondrial disorders and certain neurodegenerative diseases. Mutations or inadequate expression of MRPS22 associates with conditions such as Leigh syndrome a disorder affecting the central nervous system. In such diseases disruptions in oxidative phosphorylation pathways occur causing energy production issues. Understanding MRPS22's role helps link it to mitochondrial dysfunction contributing to these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MRPS22
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Odontology : PubMed40975852

2025

Injectable GSK3 inhibitor (Tideglusib) hydrogel versus enhanced β-tricalcium phosphate in tibial bone healing (in vitro and in vivo study).

Applications

Unspecified application

Species

Unspecified reactive species

Mahitabe Elgamily,Mona Denewar,Ahmed A Emam,Basma Hamed Othman,Nessma Sultan
View all publications
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Product promise

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