AB167406

Anti-MRPS31 antibody [EPR10707]

RabMAb
Recombinant
What is this?

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(3 Publications)

Rabbit Recombinant Monoclonal MRPS31 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

IMOGN38, MRPS31, Small ribosomal subunit protein mS31, Imogen 38, MRP-S31, S31mt

1 Images

Unknown

Western blot - Anti-MRPS31 antibody [EPR10707] (AB167406)

All lanes:

Western blot - Anti-MRPS31 antibody [EPR10707] (ab167406) at 1/1000 dilution

Lane 1:

Jurkat cell lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Lane 3:

HepG2 cell lysate at 10 µg

Lane 4:

MCF7 cell lysate at 10 µg

Predicted band size: 45 kDa

false

Carrier free

Anti-MRPS31 antibody [EPR10707] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10707

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.31% Sodium citrate, 0.175% Sodium chloride, 0.05% BSA, 0.0172% Ethylenediaminetetraacetic acid, disodium, dihydrate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRPS31 or mitochondrial ribosomal protein S31 is a component of the mitochondrial ribosome small subunit. Its molecular mass is approximately 45 kDa. MRPS31 is important in the synthesis of mitochondrial proteins since it facilitates protein translation within mitochondria. It mainly expresses in tissues with high energy demands such as muscle and brain. Mitochondrial ribosomal protein S31 is essential for maintaining mitochondrial function under different energy requirements.

Biological function summary

MRPS31 participates in the assembly and function of the mitochondrial ribosome a complex responsible for protein synthesis in mitochondria. It interacts closely with other ribosomal proteins and rRNA to ensure proper mitochondrial translation. By engaging in mitochondrial ribosome assembly MRPS31 contributes significantly to energy production and cellular metabolism supporting the high-energy needs of various types of cells.

Pathways

MRPS31 plays a significant role within oxidative phosphorylation and mitochondrial protein synthesis pathways. Oxidative phosphorylation relies on the proteins produced by the mitochondrial ribosome with MRPS31 aiding their synthesis. The mitochondrial ribosome including MRPS31 collaborates with proteins such as COX1 in the respiratory chain to ensure efficient energy generation. This integration into critical pathways emphasizes its role in cellular energy regulation and homeostasis.

MRPS31 is implicated in mitochondrial dysfunctions and neurodegenerative diseases. Mutations or dysfunctions in MRPS31 sometimes lead to disorders like mitochondrial myopathy where energy production becomes impaired. Moreover the protein's association with energy metabolism links it to Parkinson’s disease where mitochondrial deficits play a role. Direct interactions with proteins such as PINK1 in such conditions hint at its participation in disease pathogenesis and highlight its relevance in maintaining mitochondrial health.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information MRPS31

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cells 11: PubMed35805162

2022

Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection.

Applications

Unspecified application

Species

Unspecified reactive species

Seongki Min,So Mee Kwon,Jiwon Hong,Young-Kyoung Lee,Tae Jun Park,Su Bin Lim,Gyesoon Yoon

Cell death & disease 12:1076 PubMed34772924

2021

MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness.

Applications

Species

Human

Seongki Min,Young-Kyoung Lee,Jiwon Hong,Tae Jun Park,Hyun Goo Woo,So Mee Kwon,Gyesoon Yoon

Scientific reports 8:9817 PubMed29959348

2018

Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients.

Applications

Species

Human

Georgina Askeland,Zaneta Dosoudilova,Marie Rodinova,Jiri Klempir,Irena Liskova,Anna Kuśnierczyk,Magnar Bjørås,Gaute Nesse,Arne Klungland,Hana Hansikova,Lars Eide

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MRPS31 antibody [EPR10707]

Western blot - Anti-MRPS31 antibody [EPR10707] (AB167406)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise