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AB246915

Anti-MRS2/HPT antibody

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Rabbit Polyclonal MRS2/HPT antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MRS2 aa 150-350.

View Alternative Names

HPT, MRS2L, MRS2, MRS2-like protein

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRS2/HPT antibody (AB246915)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRS2/HPT antibody (AB246915)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling MRS2/HPT with ab246915 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRS2/HPT antibody (AB246915)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRS2/HPT antibody (AB246915)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling MRS2/HPT with ab246915 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRS2/HPT antibody (AB246915)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRS2/HPT antibody (AB246915)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placenta tissue labelling MRS2/HPT with ab246915 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRS2/HPT antibody (AB246915)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRS2/HPT antibody (AB246915)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling MRS2/HPT with ab246915 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Western blot - Anti-MRS2/HPT antibody (AB246915)
  • WB

Unknown

Western blot - Anti-MRS2/HPT antibody (AB246915)

All lanes:

Western blot - Anti-MRS2/HPT antibody (ab246915) at 0.4 µg/mL

All lanes:

RT4 (Human urinary bladder cancer cell line) cell lysate

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MRS2 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.

Q9HD23

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRS2 also known as HPT is a magnesium ion channel primarily found in the mitochondria. The mass of MRS2 is approximately 49 kDa. Expression of MRS2 occurs widely across different tissues indicating its essential role in cellular function. This channel facilitates the transport of magnesium ions ensuring proper mitochondrial function and contributing to cellular energy production.
Biological function summary

MRS2 acts as a critical component in the maintenance of mitochondrial magnesium homeostasis. It operates as part of the mitochondrial membrane complex allowing magnesium ions to enter the organelle. Magnesium ions are vital for numerous enzymatic processes and maintaining mitochondrial stability. Therefore MRS2's function impacts various cellular metabolic processes by supporting the enzymatic machinery within mitochondria.

Pathways

Various mitochondrial processes depend heavily on MRS2 to regulate ionic balance and support energy metabolism. The protein aligns itself with the oxidative phosphorylation pathway where it affects ATP production. Moreover MRS2 interacts with the Letm1 protein reflecting its significance in maintaining mitochondrial health and ionic equilibrium. Together these proteins ensure optimal mitochondrial performance linking MRS2 to important aspects of cellular energy pathways.

Improper function of MRS2 associates with conditions such as hypomagnesemia and familial migraines. MRS2 dysfunction can disrupt magnesium ion homeostasis leading to clinical manifestations. Additionally interactions between MRS2 and the mitochondrial protein Letm1 relate the target to epilepsy as disturbances in these interactions may exacerbate mitochondrial deficiencies linked to the disorder.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix and regulates magnesium metabolism (PubMed : 11401429, PubMed : 18384665, PubMed : 37543649, PubMed : 37938562, PubMed : 39609651). Also permeable to calcium, sodium and potassium ions (PubMed : 39609651). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed : 18384665). May play a role in maintaining the inner mitochondrial membrane potential (PubMed : 39609651).
See full target information MRS2
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