Anti-MS4A2 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

MS4A2 contributes significantly to the immune system by participating in allergic response signaling. It assembles with other subunits — alpha and gamma — to form the tetrameric IgE receptor complex. This complex on mast cells and basophils detects IgE antibodies bound to allergens triggering the release of inflammatory mediators like histamine. These mediators lead to symptoms associated with allergic reactions such as asthma and anaphylaxis. MS4A2's interaction with allergens through the receptor complex makes it an essential player in immune surveillance and response.

Pathways

MS4A2 directly influences the Fc epsilon RI signaling pathway an essential component in immune responses especially related to allergy and hypersensitivity reactions. The pathway not only involves MS4A2 but also proteins like Lyn and Syk kinase which further relay the signals initiated by antigen-IgE binding. This interaction can lead to robust downstream immune responses including inflammatory processes. The MS4A2 protein's role in this pathway connects it with other signaling cascades enhancing cell activation and response.