Rabbit Polyclonal MS4A3/HTM4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MS4A3 aa 1-50.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human MS4A3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q96HJ5
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50 - 1/200 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target data
Function
Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
Alternative names
CD20L, HTM4, MS4A3, Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4
Recommended products
Rabbit Polyclonal MS4A3/HTM4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MS4A3 aa 1-50.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human MS4A3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q96HJ5
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The MS4A3 protein also known as HTM4 acts as a mechanistic component with notable roles in cellular processes. This protein is around 34 kDa in mass and is part of the membrane-spanning 4A (MS4A) gene family which includes proteins that function as cell surface molecules. MS4A3 displays expression in various tissues especially within the hematopoietic system. Its expression in these areas suggests that it contributes to the regulation of specific biological activities.
- Biological function summary
The MS4A3 protein is involved in cell signaling and immune regulation mechanisms. As a part of the MS4A family it may interact with other proteins forming complexes that influence cellular communication. Its activity seems linked to cellular proliferation and differentiation potentially affecting how immune cells respond to different stimuli. MS4A3's role in these processes can help relay signals important for maintaining immune homeostasis.
- Pathways
The MS4A3 protein is involved in immune response and hematopoietic cell development pathways. It interfaces with CD20 (MS4A1) another member of the MS4A family to mediate B-cell activation and development. The interaction and signaling within these pathways suggest a coordination that supports the regulation of immune responses and cell maturation. These pathways illustrate the engagement of MS4A3 with other molecular components important for maintaining proper immune functions.
- Associated diseases and disorders
The MS4A3 protein has a noted association with certain hematological conditions such as leukemia. The altered expression or function of MS4A3 can impact cell signaling pathways possibly facilitating tumor progression or resistance to treatment. Additionally it connects to the protein CD20 through its involvement in immune disorders where dysregulated immune responses could lead to autoimmune diseases or immunodeficiencies. Understanding MS4A3's role in these disorders can provide insights into potential therapeutic approaches.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A3/HTM4 antibody (ab224416)
Paraffin-embedded human bone marrow tissue stained for MS4A3/HTM4 with ab224416 (1/50) in immunohistochemical analysis.
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