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AB224416

Anti-MS4A3/HTM4 antibody

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(1 Publication)

Rabbit Polyclonal MS4A3/HTM4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MS4A3 aa 1-50.

View Alternative Names

CD20L, HTM4, MS4A3, Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A3/HTM4 antibody (AB224416)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A3/HTM4 antibody (AB224416)

Paraffin-embedded human bone marrow tissue stained for MS4A3/HTM4 with ab224416 (1/50) in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MS4A3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q96HJ5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MS4A3 protein also known as HTM4 acts as a mechanistic component with notable roles in cellular processes. This protein is around 34 kDa in mass and is part of the membrane-spanning 4A (MS4A) gene family which includes proteins that function as cell surface molecules. MS4A3 displays expression in various tissues especially within the hematopoietic system. Its expression in these areas suggests that it contributes to the regulation of specific biological activities.
Biological function summary

The MS4A3 protein is involved in cell signaling and immune regulation mechanisms. As a part of the MS4A family it may interact with other proteins forming complexes that influence cellular communication. Its activity seems linked to cellular proliferation and differentiation potentially affecting how immune cells respond to different stimuli. MS4A3's role in these processes can help relay signals important for maintaining immune homeostasis.

Pathways

The MS4A3 protein is involved in immune response and hematopoietic cell development pathways. It interfaces with CD20 (MS4A1) another member of the MS4A family to mediate B-cell activation and development. The interaction and signaling within these pathways suggest a coordination that supports the regulation of immune responses and cell maturation. These pathways illustrate the engagement of MS4A3 with other molecular components important for maintaining proper immune functions.

The MS4A3 protein has a noted association with certain hematological conditions such as leukemia. The altered expression or function of MS4A3 can impact cell signaling pathways possibly facilitating tumor progression or resistance to treatment. Additionally it connects to the protein CD20 through its involvement in immune disorders where dysregulated immune responses could lead to autoimmune diseases or immunodeficiencies. Understanding MS4A3's role in these disorders can provide insights into potential therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
See full target information MS4A3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 6:420 PubMed37061660

2023

Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Xiong,Qi Cheng,Yajie Li,Yanping Han,Xin Sun,Lei Liu
View all publications
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Product promise

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