Rabbit Polyclonal MS4A3/HTM4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MS4A3 aa 1-50.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/50 - 1/200 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
CD20L, HTM4, MS4A3, Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4
Rabbit Polyclonal MS4A3/HTM4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MS4A3 aa 1-50.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
This supplementary information is collated from multiple sources and compiled automatically.
The MS4A3 protein also known as HTM4 acts as a mechanistic component with notable roles in cellular processes. This protein is around 34 kDa in mass and is part of the membrane-spanning 4A (MS4A) gene family which includes proteins that function as cell surface molecules. MS4A3 displays expression in various tissues especially within the hematopoietic system. Its expression in these areas suggests that it contributes to the regulation of specific biological activities.
The MS4A3 protein is involved in cell signaling and immune regulation mechanisms. As a part of the MS4A family it may interact with other proteins forming complexes that influence cellular communication. Its activity seems linked to cellular proliferation and differentiation potentially affecting how immune cells respond to different stimuli. MS4A3's role in these processes can help relay signals important for maintaining immune homeostasis.
The MS4A3 protein is involved in immune response and hematopoietic cell development pathways. It interfaces with CD20 (MS4A1) another member of the MS4A family to mediate B-cell activation and development. The interaction and signaling within these pathways suggest a coordination that supports the regulation of immune responses and cell maturation. These pathways illustrate the engagement of MS4A3 with other molecular components important for maintaining proper immune functions.
The MS4A3 protein has a noted association with certain hematological conditions such as leukemia. The altered expression or function of MS4A3 can impact cell signaling pathways possibly facilitating tumor progression or resistance to treatment. Additionally it connects to the protein CD20 through its involvement in immune disorders where dysregulated immune responses could lead to autoimmune diseases or immunodeficiencies. Understanding MS4A3's role in these disorders can provide insights into potential therapeutic approaches.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Paraffin-embedded human bone marrow tissue stained for MS4A3/HTM4 with ab224416 (1/50) in immunohistochemical analysis.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com