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AB189983

Anti-MS4A6A antibody - N-terminal

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(3 Publications)

Rabbit Polyclonal MS4A6A antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MS4A6A.

View Alternative Names

4SPAN3, CD20L3, MS4A6, CDA01, MSTP090, MS4A6A, Membrane-spanning 4-domains subfamily A member 6A, CD20 antigen-like 3, Four-span transmembrane protein 3

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A6A antibody - N-terminal (AB189983)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A6A antibody - N-terminal (AB189983)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labeling MS4A6A with ab189983 at 5 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A6A antibody - N-terminal (AB189983)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A6A antibody - N-terminal (AB189983)

Immunofluorescent analysis of rat brain tissue labeling MS4A6A with ab189983 at 20 μg/ml.

Western blot - Anti-MS4A6A antibody - N-terminal (AB189983)
  • WB

Supplier Data

Western blot - Anti-MS4A6A antibody - N-terminal (AB189983)

Lane 1:

Western blot - Anti-MS4A6A antibody - N-terminal (ab189983) at 1 µg/mL

Lane 2:

Western blot - Anti-MS4A6A antibody - N-terminal (ab189983) at 2 µg/mL

All lanes:

293 cell lysate

Predicted band size: 27 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human MS4A6A. The exact immunogen used to generate this antibody is proprietary information.

Q9H2W1

Specificity

At least three isoforms of MS4A6A are known to exist; ab189983 will detect the two longer isoforms. ab189983 antibody is predicted to not cross-react with MS4A family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MS4A6A also known as Membrane-Spanning 4-Domains Subfamily A Member 6A is part of the MS4A gene family and plays a role in cellular functions. It has a molecular mass of approximately 22 kDa. MS4A6A is expressed mostly in hematopoietic and immune-related tissues such as the spleen and lymph nodes. The protein structure includes four transmembrane domains which anchors it within the cell membrane allowing for potential interactions with other membrane-associated proteins.
Biological function summary

MS4A6A contributes to the regulation of immune responses and cell cycle processes. It is hypothesized to be part of larger protein complexes given its localization in membrane-rich regions. The expression pattern in immune tissues suggests involvement in modulating immune cell function. Although the exact mechanisms remain partially elucidated evidence suggests MS4A6A may interact with cell cycle regulatory proteins and receptors influencing immune cell signaling and proliferation.

Pathways

This protein appears integral to pathways regulating immune signaling and cell communication. It participates in pathways such as the B-cell receptor (BCR) signaling. Related proteins within these pathways include other members of the MS4A family such as MS4A1 (CD20) which also contributes to immune cell signaling. Its involvement helps relay signals from the cell surface to the inside mediating various downstream effects essential for proper immune function.

MS4A6A has been linked to neurodegenerative diseases including Alzheimer's disease. It may interact with proteins like amyloid-beta peptides through its potential modulation of neuroinflammatory responses. Another disease association includes its involvement in certain lymphoid malignancies where aberrations lead to disrupted cell cycle regulation. Proteins in pathways associated with these diseases such as CD20 often share functional similarities and relevance making MS4A6A a target of interest for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in signal transduction as a component of a multimeric receptor complex.
See full target information MS4A6A
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Molecular neurodegeneration 20:94 PubMed40877951

2025

MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer's disease model.

Applications

Unspecified application

Species

Unspecified reactive species

Hai-Shan Jiao,Yi-Jun Ge,Liang-Yu Huang,Ying Liu,Bang-Sheng Wu,Piao-Piao Lian,Yi-Ning Hao,Shan-Shan Han,Yi-Ting Li,Kai-Min Wu,Chen-Yun Wu,Tian-Lin Cheng,Peng Yuan,Jin-Tai Yu

The European journal of neuroscience 59:2836-2849 PubMed38488530

2024

Involvement of microglia-expressed MS4A6A in the onset of glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenhao Lv,Shengyan Lin,Zhenxing Zuo,Zhihui Huang,Yongjie Wang

Aging 14:2268-2286 PubMed35255005

2022

A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1.

Applications

Unspecified application

Species

Unspecified reactive species

Xiwu Ouyang,Lemeng Feng,Lei Yao,Jingyu Zhang,Yao Xiao,Guodong Liu,Gewen Zhang,Zhiming Wang
View all publications
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Product promise

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