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Rabbit Polyclonal MS4A6A antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human, Rat samples. Immunogen corresponding to Synthetic Peptide within Human MS4A6A.

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Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human MS4A6A. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H2W1
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Rat
Expected
Tested

Tested
Tested

Species

Human

Dilution info

1.00000-2.00000 µg/mL

Notes

-

Expected
Expected

Species

Rat

Dilution info

Use at an assay dependent concentration.

Notes

-

Tested
Tested

Species

Rat

Dilution info

5 µg/mL

Notes

-

Species

Human

Dilution info

5 µg/mL

Notes

-

Target data

Function

May be involved in signal transduction as a component of a multimeric receptor complex.

Alternative names

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Rabbit Polyclonal MS4A6A antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human, Rat samples. Immunogen corresponding to Synthetic Peptide within Human MS4A6A.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen

Synthetic Peptide within Human MS4A6A. The exact immunogen used to generate this antibody is proprietary information.Database link Q9H2W1

Purification technique

Affinity purification Immunogen

Specificity

At least three isoforms of MS4A6A are known to exist; ab189983 will detect the two longer isoforms. ab189983 antibody is predicted to not cross-react with MS4A family members.

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological summary

MS4A6A contributes to the regulation of immune responses and cell cycle processes. It is hypothesized to be part of larger protein complexes given its localization in membrane-rich regions. The expression pattern in immune tissues suggests involvement in modulating immune cell function. Although the exact mechanisms remain partially elucidated evidence suggests MS4A6A may interact with cell cycle regulatory proteins and receptors influencing immune cell signaling and proliferation.

Mechanical summary

MS4A6A also known as Membrane-Spanning 4-Domains Subfamily A Member 6A is part of the MS4A gene family and plays a role in cellular functions. It has a molecular mass of approximately 22 kDa. MS4A6A is expressed mostly in hematopoietic and immune-related tissues such as the spleen and lymph nodes. The protein structure includes four transmembrane domains which anchors it within the cell membrane allowing for potential interactions with other membrane-associated proteins.

Pathway

This protein appears integral to pathways regulating immune signaling and cell communication. It participates in pathways such as the B-cell receptor (BCR) signaling. Related proteins within these pathways include other members of the MS4A family such as MS4A1 (CD20) which also contributes to immune cell signaling. Its involvement helps relay signals from the cell surface to the inside mediating various downstream effects essential for proper immune function.

Disease

MS4A6A has been linked to neurodegenerative diseases including Alzheimer's disease. It may interact with proteins like amyloid-beta peptides through its potential modulation of neuroinflammatory responses. Another disease association includes its involvement in certain lymphoid malignancies where aberrations lead to disrupted cell cycle regulation. Proteins in pathways associated with these diseases such as CD20 often share functional similarities and relevance making MS4A6A a target of interest for therapeutic interventions.

Product promise

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3 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A6A antibody - N-terminal (ab189983), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A6A antibody - N-terminal (ab189983)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labeling MS4A6A with ab189983 at 5 μg/ml.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A6A antibody - N-terminal (ab189983), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MS4A6A antibody - N-terminal (ab189983)

    Immunofluorescent analysis of rat brain tissue labeling MS4A6A with ab189983 at 20 μg/ml.

  • Western blot - Anti-MS4A6A antibody - N-terminal (ab189983), expandable thumbnail

    Western blot - Anti-MS4A6A antibody - N-terminal (ab189983)

    Lane 1: Western blot - Anti-MS4A6A antibody - N-terminal (AB189983) at 1 µg/mL

    Lane 2: Western blot - Anti-MS4A6A antibody - N-terminal (AB189983) at 2 µg/mL

    All lanes: 293 cell lysate

    Predicted band size: 27 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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