AB114099

Anti-MSF antibody

Name: Anti-MSF antibody (ab114099) | Abcam
Brand: Abcam Limited
SKU: AB114099

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(3 Publications)

Rabbit Polyclonal MSF antibody. Suitable for IP, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SEPTIN9 aa 500 to C-terminus.

View Alternative Names

KIAA0991, MSF, SEPT9, SEPTIN9, Septin-9, MLL septin-like fusion protein MSF-A, Ovarian/Breast septin, Septin D1, MLL septin-like fusion protein, Ov/Br septin

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSF antibody (AB114099)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSF antibody (AB114099)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling MSF with ab114099 at 1/1000 (1µg/ml). A DyLight® 594-conjugated goat anti-rabbit IgG (H+L) (1/100) was used as the secondary antibody.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IP, IHC-P

applications

Immunogen

Synthetic Peptide within Human SEPTIN9 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UHD8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/5000", "IHCP-species-notes": "<p></p>" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab114099 was affinity purified using an epitope specific to MSF immobilized on solid support.

Storage buffer

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MSF also known as Myeloid Differentiation Factor 88 (MYD88) scaffolding factor or stromal cell-derived factor (SDF) is a protein that acts as a signaling molecule. It has an approximate molecular weight of 33 kDa. This protein is important in cell signaling pathways particularly during the immune response. Expression of MSF occurs broadly in immune cells including macrophages and dendritic cells. Its main role is to mediate the cellular response to pathogens by activating downstream signaling pathways.

Biological function summary

MSF functions as a facilitator of signal transduction especially within immune cells. It is not part of a complex but acts as a scaffold bringing together various signaling molecules to enable effective communication within the cell. MSF works to regulate immune responses by interacting with several key proteins involved in pathogen recognition and response promoting the activation of immune-related genes.

Pathways

MSF plays a significant role in the Toll-like receptor (TLR) signaling pathway. It functions to transmit signals from TLRs to activate transcription factors like NF-kB. Additionally MSF is involved in the IL-1 receptor pathway where it interacts with proteins such as Interleukin-1 receptor-associated kinases (IRAKs). These pathways orchestrate inflammatory responses making MSF integral in maintaining proper immune function.

MSF has been associated with autoimmune disorders and certain cancers. Its dysregulation can lead to inappropriate activation of the immune system contributing to conditions such as systemic lupus erythematosus. Some studies have linked MSF with lymphoma where it interacts with proteins like BTK affecting cellular proliferation. Understanding MSF's role in these diseases may provide opportunities for targeted therapies and improved treatments.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

See full target information SEPTIN9

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell discovery 8:130 PubMed36473865

2022

The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Boyu Zhang,Qingxin Liu,Weijie Wen,Han Gao,Wenxia Wei,Aiwen Tang,Baifu Qin,Haiwen Lyu,Xiangqi Meng,Kai Li,Huilin Jin,Fenghai Yu,Qihao Pan,Junzhong Lin,Mong-Hong Lee

iScience 25:104288 PubMed35573204

2022

Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets.

Applications

Unspecified application

Species

Unspecified reactive species

Pei Xuan Song,Juan Peng,Mohyeddine Omrane,Ting Ting Cai,Didier Samuel,Ama Gassama-Diagne

The Journal of cell biology 220: PubMed33861319

2021

FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Chen,Bing Yan,Jie Ren,Rui Lyu,Yanfang Wu,Yuting Guo,Dong Li,Hong Zhang,Junjie Hu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MSF antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSF antibody (AB114099)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise