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AB76822

Anti-MSP/MST1 antibody

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(4 Publications)

Mouse Polyclonal MSP/MST1 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.

View Alternative Names

D3F15S2, DNF15S2, HGFL, MST1, Hepatocyte growth factor-like protein, Macrophage stimulatory protein, Macrophage-stimulating protein, MSP

1 Images
Western blot - Anti-MSP/MST1 antibody (AB76822)
  • WB

Unknown

Western blot - Anti-MSP/MST1 antibody (AB76822)

All lanes:

Western blot - Anti-MSP/MST1 antibody (ab76822) at 1/500 dilution

Lane 1:

MSP/MST1-transfected 293T cell line at 25 µg

Lane 2:

Non-transfected 293T cell line at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L) HRP-conjugated at 1/2500 dilution

Predicted band size: 80 kDa

Observed band size: 80 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MSP/MST1 also known as macrophage stimulating protein is a serine protease family protein with a molecular mass of approximately 80 kDa. It expresses in various tissues with significant presence in liver tissue. MST1 is a precursor protein that undergoes proteolytic cleavage to become its active form. MSP protein plays an important role in signaling processes acting as a ligand for the RON receptor tyrosine kinase triggering downstream effects in various cellular systems.
Biological function summary

MSP protein contributes to numerous cellular events including migration differentiation and survival. It forms a complex with the RON receptor facilitating cell signaling cascades that influence these processes. MSP is key in the regulation of immune responses and tissue remodeling which makes it significant in inflammation and wound healing contexts. It influences macrophage activity promoting their ability to clear pathogens and repair tissues.

Pathways

MSP protein is integral to the HGF/MET signaling pathway and the related MSP/RON pathway. These pathways are involved in cellular growth motility and morphogenesis with a notable impact on epithelial cellular dynamics. MST1 through its interaction with RON influences c-Met and related pathways that intertwine with cell cycle regulation. The crosstalk with hepatocyte growth factor (HGF) can further elucidate the sophisticated regulation of cellular functions where MSP plays a role.

MSP protein has been implicated in cancer progression and inflammatory diseases. It associates closely with the progression of certain carcinomas through its interaction with the RON receptor influencing tumor proliferation and metastasis. Additionally the dysregulation of MSP is associated with chronic inflammatory conditions linking it to key pathway proteins such as HGF. The therapeutic targeting of MSP might offer insights into anticancer and anti-inflammatory treatment strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MST1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer management and research 13:4829-4840 PubMed34168502

2021

Downregulation of MicroRNA-130a Inhibits Oral Squamous Cell Carcinoma Proliferation and Metastasis via the Hippo-YAP Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yiran Peng,Shoushan Hu,Kun Zhang,Yuru Wang,Maierdanjiang Rouzi,Dan Zhou,Ran Yang

BMC pregnancy and childbirth 20:652 PubMed33109096

2020

circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Yonggang Zhang,Hongling Yang,Yipeng Zhang,Junzhu Shi,Ronggui Chen

Journal of ethnopharmacology 240:111954 PubMed31085225

2019

The ethyl acetate extracts of radix trichosanthis protect retinal vascular endothelial cells from high glucose-induced injury.

Applications

Unspecified application

Species

Unspecified reactive species

Yongli Song,Zhenglin Wang,Hongli Li,Wei Xing,Yan Wu,Chun Li,Yonggang Liu,Jing Han,Wei Wang

International journal of oncology 52:815-827 PubMed29393390

2018

miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Manman Xu,Juan Xiao,Ming Chen,Linjing Yuan,Jundong Li,Hongwei Shen,Shuzhong Yao
View all publications
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