JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB317410

Anti-MSP/MST1 antibody [S04-1D6]

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Monoclonal MSP/MST1 antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Immunogen corresponding to Synthetic Peptide within Human MST1.

View Alternative Names

D3F15S2, DNF15S2, HGFL, MST1, Hepatocyte growth factor-like protein, Macrophage stimulatory protein, Macrophage-stimulating protein, MSP

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSP/MST1 Antibody [S04-1D6] (AB317410)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSP/MST1 Antibody [S04-1D6] (AB317410)

Immunohistochemistry of MSP/MST1 in paraffin-embedded human colon cancer tissue using ab317410 at dilution 1/50.

Western blot - Anti-MSP/MST1 Antibody [S04-1D6] (AB317410)
  • WB

Supplier Data

Western blot - Anti-MSP/MST1 Antibody [S04-1D6] (AB317410)

All lanes:

Western blot - Anti-MSP/MST1 Antibody [S04-1D6] (ab317410) at 1/1000 dilution

Lane 1:

HeLa cell lysate

Lane 2:

C6 cell lysate

Lane 3:

Rat brain lysate

Predicted band size: 80 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S04-1D6

Isotype

IgG

Carrier free

No

Reacts with

Human, Rat

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human MST1.

P26927

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MSP/MST1 also known as macrophage stimulating protein is a serine protease family protein with a molecular mass of approximately 80 kDa. It expresses in various tissues with significant presence in liver tissue. MST1 is a precursor protein that undergoes proteolytic cleavage to become its active form. MSP protein plays an important role in signaling processes acting as a ligand for the RON receptor tyrosine kinase triggering downstream effects in various cellular systems.
Biological function summary

MSP protein contributes to numerous cellular events including migration differentiation and survival. It forms a complex with the RON receptor facilitating cell signaling cascades that influence these processes. MSP is key in the regulation of immune responses and tissue remodeling which makes it significant in inflammation and wound healing contexts. It influences macrophage activity promoting their ability to clear pathogens and repair tissues.

Pathways

MSP protein is integral to the HGF/MET signaling pathway and the related MSP/RON pathway. These pathways are involved in cellular growth motility and morphogenesis with a notable impact on epithelial cellular dynamics. MST1 through its interaction with RON influences c-Met and related pathways that intertwine with cell cycle regulation. The crosstalk with hepatocyte growth factor (HGF) can further elucidate the sophisticated regulation of cellular functions where MSP plays a role.

MSP protein has been implicated in cancer progression and inflammatory diseases. It associates closely with the progression of certain carcinomas through its interaction with the RON receptor influencing tumor proliferation and metastasis. Additionally the dysregulation of MSP is associated with chronic inflammatory conditions linking it to key pathway proteins such as HGF. The therapeutic targeting of MSP might offer insights into anticancer and anti-inflammatory treatment strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information MST1

Additional targets

Bhlha15
style
left-column
style
left-column
style
right-column

Complementary Products

Assay Kits

AB256390

Mouse MSP ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Mouse MSP ELISA Kit (AB256390)

  • 0
  • 0
Primary Antibodies

AB52641

Anti-STK3/MST-2 antibody [EP1466Y]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK3/MST-2 antibody [EP1466Y] (AB52641)

  • 0
  • 0
Primary Antibodies

AB76323

Anti-MST1/MST2 (phospho T180 + T183) antibody [EPR1467Y]

RabMAb|Recombinant

Western blot - Anti-MST1/MST2 (phospho T180 + T183) antibody [EPR1467Y] (AB76323)

  • 1
  • 1
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB205270

Anti-active YAP1 antibody [EPR19812]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-active YAP1 antibody [EPR19812] (AB205270)

  • 5
  • 25

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com