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AB229940

Anti-MSRB2 antibody

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(1 Publication)

Rabbit Polyclonal MSRB2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MSRB2 aa 1 to C-terminus.

View Alternative Names

CBS-1, MSRB, CGI-131, MSRB2, MsrB2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSRB2 antibody (AB229940)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSRB2 antibody (AB229940)

Paraffin-embedded human colon cancer tissue stained for MSRB2 using ab229940 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-MSRB2 antibody (AB229940)
  • WB

Supplier Data

Western blot - Anti-MSRB2 antibody (AB229940)

All lanes:

Western blot - Anti-MSRB2 antibody (ab229940) at 1/1000 dilution

Lane 1:

Mouse heart tissue lysate

Lane 2:

Mouse brain tissue lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 20 kDa

Observed band size: 20 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human MSRB2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y3D2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target MSRB2 also known as methionine sulfoxide reductase B2 is an enzyme involved in the repair of oxidized proteins. Mechanically MSRB2 reduces methionine-R-sulfoxide back to methionine using thioredoxin as an electron donor. MSRB2 has a molecular mass of approximately 20 kDa and is expressed in various cells and tissues with notable expression in mitochondria which suggests its functional significance in cellular oxidative stress response.
Biological function summary

MSRB2 plays a role in cellular defense against oxidative damage. Its ability to repair oxidatively modified proteins helps maintain protein function and cellular homeostasis. MSRB2 does not typically form complexes but operates in conjunction with other antioxidant enzymes enhancing cellular resistance to stress. Its presence in mitochondria highlights its contribution to mitochondrial integrity and function which are key for energy production and apoptosis regulation.

Pathways

MSRB2 participates in redox regulation and antioxidant defense pathways. It influences the oxidative stress response pathway important in protecting cells from damage caused by reactive oxygen species. MSRB2 interacts with proteins like thioredoxin which assists its enzymatic activity and plays a role in maintaining the redox balance within the cell. MSRB2 through its activity ensures proteins returning to their reduced forms contributing significantly to cellular health.

MSRB2 has been connected to conditions involving oxidative stress such as neurodegenerative diseases and heart disease. Lower levels or dysfunctional MSRB2 can lead to increased oxidative damage contributing to the progression of disorders like Alzheimer's disease. Furthermore its relationship with thioredoxin and other redox-related proteins may influence disease pathways where oxidative stress is implicated. Understanding MSRB2's function aids in developing therapies targeting oxidative stress-related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.
See full target information MSRB2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 14:760 PubMed37993451

2023

The BRD4-SRPK2-SRSF2 signal modulates the splicing efficiency of ACSL3 pre-mRNA and influences erastin-induced ferroptosis in osteosarcoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shun-Hong Luo,Jia-Ming Tian,Yi Chu,Hong-Yi Zhu,Jiang-Dong Ni,Jun Huang
View all publications
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Product promise

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