AB233127

Anti-MSS1 antibody

Name: Anti-MSS1 antibody (ab233127) | Abcam
Brand: Abcam Limited
SKU: AB233127

Be the first to review this product! Submit a review

(3 Publications)

Rabbit Polyclonal MSS1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PSMC2.

View Alternative Names

MSS1, PSMC2, 26S proteasome regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSS1 antibody (AB233127)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSS1 antibody (AB233127)

Formalin-fixed, paraffin-embedded human kidney tissue stained for MSS1 using ab233127 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-MSS1 antibody (AB233127)

All lanes:

Western blot - Anti-MSS1 antibody (ab233127) at 2 µg/mL

All lanes:

Recombinant human Proteasome 19S S7 protein.

Predicted band size: 49 kDa

false

Supplier Data

Western blot - Anti-MSS1 antibody (AB233127)

All lanes:

Western blot - Anti-MSS1 antibody (ab233127) at 2 µg/mL

All lanes:

U-2 OS (human bone osteosarcoma epithelial cell line) cell lysate

Predicted band size: 49 kDa

false

Supplier Data

Western blot - Anti-MSS1 antibody (AB233127)

All lanes:

Western blot - Anti-MSS1 antibody (ab233127) at 2 µg/mL

All lanes:

Mouse liver tissue lysate

Predicted band size: 49 kDa

false

Supplier Data

Western blot - Anti-MSS1 antibody (AB233127)

All lanes:

Western blot - Anti-MSS1 antibody (ab233127) at 2 µg/mL

All lanes:

Mouse spleen tissue lysate

Predicted band size: 49 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PSMC2.

P35998

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MSS1 also known as Mitochondrial Stress Sensitive 1 is a protein that plays a role in cellular processes. It has an approximate mass of 27 kDa. MSS1 expresses in various tissues with higher levels observed in mitochondria-rich tissues indicating a role in energy metabolism. Primarily the protein operates within the mitochondria where it takes part in maintaining cellular homeostasis.

Biological function summary

MSS1 contributes to the regulation of mitochondrial function and integrity. It is involved in the formation and maintenance of mitochondrial membranes and assists in mitochondrial protein translocation. As part of the TIM22 complex MSS1 is responsible for the insertion and assembly of membrane proteins into the inner mitochondrial membrane playing a role in efficient energy production and overall cellular respiration.

Pathways

MSS1 contributes significantly to the oxidative phosphorylation and mitochondrial protein import pathways. Within these pathways it interacts with the TIM22 complex facilitating the integration of translocase-associated proteins into the inner membrane. This interaction is important for maintaining mitochondrial structure and function supporting energy metabolism in cells. Additionally MSS1's function closely relates to proteins like TIM23 and TIM44 which also help in protein translocation and integration within the mitochondria.

MSS1 is linked to conditions such as mitochondrial myopathy and mitochondrial encephalomyopathy. These disorders often involve defects in mitochondrial function and energy metabolism. Anomalies in MSS1 expression or function could impact the integration of proteins into the mitochondrial membrane leading to impaired mitochondrial function. MSS1's role in these disorders often involves interaction with other mitochondrial import machinery components like TIM44 which may also influence pathological outcomes.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

See full target information PSMC2

style

left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Physiological reports 13:e70580 PubMed40999314

2025

High-intensity interval training attenuates cardiac injury by targeting ferroptosis and endoplasmic reticulum-stress in male rats with heart failure.

Applications

Unspecified application

Species

Unspecified reactive species

Aida Sabouri,Abbasali Gaeini,Soheila Adeli,Alireza Ghardashi Afousi

Cell cycle (Georgetown, Tex.) 21:477-488 PubMed34979867

2022

PSMC2 knockdown inhibits the progression of oral squamous cell carcinoma by promoting apoptosis via PI3K/Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zijia Wang,Haofeng Xiong,Yijie Zuo,Shujun Hu,Chao Zhu,Anjie Min

Calcified tissue international 109:44-54 PubMed33625534

2021

Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Zhou,Kun Peng,Guoqiang Wang,Weihua Chen,Yijun Kang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MSS1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSS1 antibody (AB233127)

Western blot - Anti-MSS1 antibody (AB233127)

Western blot - Anti-MSS1 antibody (AB233127)

Western blot - Anti-MSS1 antibody (AB233127)

Western blot - Anti-MSS1 antibody (AB233127)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise