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AB96705

Anti-MST3 antibody

4

(2 Reviews)

|

(2 Publications)

Rabbit Polyclonal MST3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human STK24 aa 100-200.

View Alternative Names

MST3, STK3, STK24, Serine/threonine-protein kinase 24, Mammalian STE20-like protein kinase 3, STE20-like kinase MST3, MST-3

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-MST3 antibody (AB96705)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MST3 antibody (AB96705)

Immunofluorescence analysis of MST3 in paraformaldehyde-fixed HeLa cells, using ab96705 at 1/200 dilution (top image) and merged with DNA probe (bottom image).

Western blot - Anti-MST3 antibody (AB96705)
  • WB

Unknown

Western blot - Anti-MST3 antibody (AB96705)

10% SDS-PAGE

All lanes:

Western blot - Anti-MST3 antibody (ab96705) at 1/1000 dilution

All lanes:

Raji whole cell lysate at 30 µg

Predicted band size: 49 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human STK24 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6E0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Mammalian Sterile 20-like kinase 3 also known as MST3 or STK24 is a serine/threonine protein kinase with a mass of approximately 49 kDa. MST3 belongs to the STE20 group of kinases which play roles in various cellular processes. It localizes primarily in the cytoplasm and nucleus and sees significant expression in the brain heart liver and skeletal muscles. MST3 also associates with cellular structures such as the Golgi apparatus suggesting a role in intracellular transport or signaling.
Biological function summary

MST3 participates in regulating cell proliferation apoptosis and migration. It is not part of a larger complex but works closely with other signaling proteins to influence these processes. MST3 impacts cytoskeletal organization contributing to the dynamic remodeling of actin filaments. This protein also affects the apoptotic pathways by modulating the interactions with other kinases and apoptosis-related factors thereby aiding in the maintenance of cellular homeostasis.

Pathways

MST3 plays significant roles in the Hippo signaling pathway and the MAPK pathway—both critical for cell growth survival and differentiation. MST3 shares pathways with kinases like MOB1 and NDR1/2 in the Hippo pathway where it assists in regulating cell proliferation and apoptosis. In the context of MAPK signaling MST3 interacts with and is regulated by RAF1 and MEK1/2 coordinating cell stress responses and signaling cascades.

MST3 has associations with neurological disorders and cancer. In the context of neurological disorders MST3 activity affects neuronal apoptosis and tau phosphorylation processes that relate to neurodegenerative diseases. In cancer biology MST3 regulates apoptosis and proliferation and its dysregulation might contribute to tumorigenesis. MST3 connects with proteins such as BCL2 and PARP1 that also influence these disease states making it a protein of interest for therapeutic research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed : 27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation : phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed : 18782753).
See full target information STK24
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 23:192 PubMed40055697

2025

NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium.

Applications

Unspecified application

Species

Unspecified reactive species

Xue-Xue Zhu,An-Jing Xu,Wei-Wei Cai,Zhi-Jun Han,Shi-Jie Zhang,Bao Hou,Yuan-Yuan Wen,Xing-Yu Cao,Hao-Dong Li,Yue-Qing Du,You-Yi Zhuang,Jing Wang,Xiao-Ran Hu,Xin-Ran Bai,Jia-Bao Su,Ao-Yuan Zhang,Qing-Bo Lu,Ye Gu,Li-Ying Qiu,Lin Pan,Hai-Jian Sun

Cell proliferation 52:e12564 PubMed30938030

2019

Suppression of long non-coding RNA TNRC6C-AS1 protects against thyroid carcinoma through DNA demethylation of STK4 via the Hippo signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liu-Xue Yang,Ji Wu,Man-Li Guo,Yong Zhang,Shao-Gang Ma
View all publications
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