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AB198860

Anti-MT-CYB antibody

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Rabbit Polyclonal MT-CYB antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MT-CYB.

View Alternative Names

COB, CYTB, MTCYB, MT-CYB, Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MT-CYB antibody (AB198860)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MT-CYB antibody (AB198860)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver cancer tissue labeling MT-CYB with ab198860 at 1/30 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MT-CYB antibody (AB198860)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MT-CYB antibody (AB198860)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lthyroid cancer tissue labeling MT-CYB with ab198860 at 1/30 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MT-CYB. The exact immunogen used to generate this antibody is proprietary information.

P00156

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MT-CYB also known as cytochrome b is part of the mitochondrial inner membrane. It plays a fundamental role in electron transport during cellular respiration. The target is sometimes referred to by alternate names such as cytochrome b complex III subunit although the mass of MT-CYB varies depending on its specific isoform. You can find MT-CYB expressed within the mitochondria of nearly all eukaryotic cells where it contributes to energy production.
Biological function summary

MT-CYB facilitates the transfer of electrons from ubiquinol to cytochrome c. It forms part of the complex III also known as the cytochrome bc1 complex which plays a significant role in the mitochondrial electron transport chain. Through this electron transport process MT-CYB contributes to the formation of a proton gradient across the inner mitochondrial membrane that is essential for ATP synthesis the main energy currency of cells.

Pathways

MT-CYB engages in key steps of the oxidative phosphorylation pathway and the tricarboxylic acid cycle. It closely interacts with other components such as cytochrome c1 and Rieske iron-sulfur protein within the complex III. Together these proteins facilitate the transfer of electrons through the pathway ultimately leading to the generation of ATP.

Mutations in MT-CYB are often associated with mitochondrial diseases like MELAS (Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like episodes) and LHON (Leber's Hereditary Optic Neuropathy). These diseases can arise due to malfunction in energy production. MT-CYB mutations can also interact with other mitochondrial proteins such as NADH dehydrogenase exacerbating the disease manifestations through impaired electron transport and reduced ATP synthesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
See full target information MT-CYB
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