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AB193329

Anti-MT1G antibody

1

(1 Review)

|

(1 Publication)

Rabbit Polyclonal MT1G antibody. Suitable for ELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MT1G aa 1 to C-terminus.

View Alternative Names

MT1K, MT1M, MT1G, Metallothionein-1G, MT-1G, Metallothionein-1K, Metallothionein-IG, MT-1K, MT-IG

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ELISA

applications

Immunogen

Recombinant Fragment Protein within Human MT1G aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P13640

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
>95%,Protein G purified
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MT1G known as Metallothionein 1G is a protein involved in binding heavy metals such as copper and zinc. The protein has a molecular mass of approximately 6 to 7 kDa. It expresses in various tissues including the liver kidneys and brain. MT1G plays a role in maintaining metal ion homeostasis by binding and sequestering metal ions preventing potential toxicity. It is also known for its strong antioxidant properties offering protection against oxidative stress.
Biological function summary

Metallothionein 1G acts as a metal-binding protein contributing to detoxification processes and protecting cells from metal-induced damage. MT1G does not seem to form large multiprotein complexes but it interacts with metal ions regulating their availability in cellular environments. The protective effect of MT1G extends to the repair of DNA by mitigating the damage caused by oxidative stress which helps maintain cellular integrity under challenging conditions.

Pathways

Metallothionein 1G participates in metal ion homeostasis and oxidative stress response pathways. It modulates the availability of essential metals like zinc interacting with proteins such as zinc transporters. MT1G may also play a role in signal transduction pathways influenced by zinc. By controlling metal ion concentrations it helps regulate various cellular functions including gene expression and enzyme activity.

MT1G has significant associations with cancer and neurodegenerative diseases. In cancers changes in MT1G expression levels relate to tumor resistance and progression with possible interactions occurring with proteins like p53 a well-known tumor suppressor. In neurodegenerative disorders MT1G supports neuronal protection and function possibly interacting with amyloid precursor protein in Alzheimer's disease where it may assist in reducing amyloid toxicity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
See full target information MT1G
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Genetics and molecular biology 45:e20210067 PubMed35167648

2022

MT1G inhibits the growth and epithelial-mesenchymal transition of gastric cancer cells by regulating the PI3K/AKT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Guofeng Xu,Linfeng Fan,Shufeng Zhao,Canhui OuYang
View all publications
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Product promise

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