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AB115529

Anti-MTBP antibody

4

(2 Reviews)

|

(3 Publications)

Rabbit Polyclonal MTBP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MTBP aa 100-150 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Mdm2-binding protein, hMTBP, MTBP

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTBP antibody (AB115529)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTBP antibody (AB115529)

ab115529 at 10ug/ml staining MTBP in Formalin-fixed, Paraffin-embedded Human thymus tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTBP antibody (AB115529)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTBP antibody (AB115529)

ab115529 at 10ug/ml staining MTBP in Formalin-fixed, Paraffin-embedded Human tonsil tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MTBP aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q96DY7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MTBP also known as Mdm2-binding protein interacts mechanically with the Mdm2 protein. It has a molecular mass of approximately 125 kDa. MTBP expresses in many tissues with high levels notably in the brain and testes. The expression pattern suggests diverse roles in cellular functioning and development.
Biological function summary

MTBP participates in the regulation of cell proliferation and survival. It acts as a part of the regulatory complex influencing the p53 pathway which is important for controlling the cell cycle and apoptosis. The interaction with Mdm2 affects the stability and activity of the p53 protein an essential factor in preventing abnormal cell growth.

Pathways

MTBP has a significant role in the cell cycle regulation and DNA damage response pathways. It is widely associated with the p53 pathway involving p53 and Mdm2 proteins. The regulation of these pathways is fundamental in maintaining genomic integrity and cellular response following DNA damage.

MTBP's misregulation associates with cancer development. Its interaction with Mdm2 and p53 reveals a potential link to tumorigenesis as the imbalance can lead to uncontrollable cell growth. Abnormal activity or expression of MTBP also shows association with glioblastoma an aggressive brain cancer due to its regulatory effects on cell cycle and survival pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
See full target information MTBP
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Animal cells and systems 25:152-160 PubMed34262658

2021

MTBP promoted the proliferation, migration and invasion of colon cancer cells by activating the expression of ZEB2.

Applications

Unspecified application

Species

Unspecified reactive species

Paerhati Shayimu,Aikeremu Yusufu,Aizimaiti Rehemutula,Darebai Redati,Rexida Jiapaer,Rousidan Tuerdi

Theranostics 9:6019-6030 PubMed31534534

2019

MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas.

Applications

Unspecified application

Species

Unspecified reactive species

Yifu Song,Li Zhang,Yang Jiang,Tianhao Hu,Di Zhang,Qiao Qiao,Run Wang,Minghao Wang,Sheng Han

Oncology letters 14:6409-6416 PubMed29422956

2017

MDM2 binding protein as a predictor of metastasis and a novel prognostic biomarker in patients with gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wang,Zhong Chen,Jiejie Jin,Ziwen Long,Xiaowen Liu,Hong Cai,Ye Zhou,Hua Huang,Yanong Wang
View all publications
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Product promise

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