AB230006

Anti-MTCH1/PSAP antibody

Name: Anti-MTCH1/PSAP antibody (ab230006) | Abcam
Brand: Abcam Limited
SKU: AB230006

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(1 Publication)

Rabbit Polyclonal MTCH1/PSAP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MTCH1 aa 100-250.

View Alternative Names

PSAP, CGI-64, UNQ1871/PRO4314, MTCH1, Mitochondrial carrier homolog 1, Presenilin-associated protein

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTCH1/PSAP antibody (AB230006)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTCH1/PSAP antibody (AB230006)

Paraffin-embedded human brain tissue stained for MTCH1/PSAP using ab230006 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTCH1/PSAP antibody (AB230006)

Paraffin-embedded human liver tissue stained for MTCH1/PSAP using ab230006 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-MTCH1/PSAP antibody (AB230006)

All lanes:

Western blot - Anti-MTCH1/PSAP antibody (ab230006) at 1/1000 dilution

Lane 1:

MCF7 (human breast adenocarcinoma cell line) whole cell lysate

Lane 2:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 42 kDa

Observed band size: 42 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human MTCH1 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q9NZJ7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein MTCH1 also known as PSAP or mitochondrial carrier homolog 1 plays an important role in mitochondrial processes. With a mass of approximately 43 kDa it is expressed mainly in mitochondria-rich tissues found prominently in human skeletal muscle and heart. MTCH1 localizes to the outer mitochondrial membrane where it likely participates in the regulation of apoptosis by interacting with other mitochondrial proteins.

Biological function summary

Mitochondria-associated MTCH1 influences apoptosis and energy regulation. It acts as a pro-apoptotic factor and is observed to bind with the proapoptotic protein Bax which promotes mitochondrial outer membrane permeabilization. Through this involvement it becomes part of a complex interplay between pro- and anti-apoptotic molecules that regulates cell death pathways responding to cellular stress signals.

Pathways

The protein MTCH1 holds significance in mitochondrial apoptosis and energy homeostasis pathways. It closely associates with the Bcl-2 protein family which includes key proteins involved in the intrinsic apoptotic pathway. MTCH1 influences cellular fate decisions by affecting the mitochondrial apoptotic pathway alongside proteins such as Bcl-xL and Bax thereby regulating cell survival and death.

The mitochondrial functions of MTCH1 relates it to neurodegenerative diseases and cancers. Abnormalities in MTCH1 expression can contribute to mitochondrial dysfunction linking it to disorders such as Alzheimer's disease. This connection involves MTCH1 interaction with proteins like Bcl-2 influencing the disease's progress through apoptotic dysregulation. MTCH1's role in apoptosis also associates it with various cancers where its abnormal expression impacts cell death regulation and tumor progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed : 36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (By similarity). Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). May play a role in apoptosis (PubMed : 12377771).

See full target information MTCH1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 16:1047 PubMed40493298

2025

TCF19 expression and significance analysis in breast cancer: integrated bioinformatics analysis and histological validation.

Applications

Unspecified application

Species

Unspecified reactive species

Haiyang Yu,Jingjing Wei,Qinhao Chen,Yueyin Pan,Xiaojun Qian,Jing Pan,Yubei Sun

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-MTCH1/PSAP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTCH1/PSAP antibody (AB230006)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTCH1/PSAP antibody (AB230006)

Western blot - Anti-MTCH1/PSAP antibody (AB230006)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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