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AB242093

Anti-MTFR1 antibody

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Rabbit Polyclonal MTFR1 antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MTFR1 aa 250 to C-terminus.

View Alternative Names

CHPPR, FAM54A2, KIAA0009, MTFR1, Mitochondrial fission regulator 1, Chondrocyte protein with a poly-proline region

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Immunoprecipitation - Anti-MTFR1 antibody (AB242093)
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Supplier Data

Immunoprecipitation - Anti-MTFR1 antibody (AB242093)

MTFR1 was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab242093 at 8 μl/reaction. Western blot was performed from the immunoprecipitate using ab242093 at 1/1000 dilution.

Lane 1 : ab242093 IP in HeLa whole cell lysate.
Lane 2 : Control IgG IP in HeLa whole cell lysate.

Detection : Chemiluminescence with exposure time of 30 seconds.

Lysates prepared in NETN buffer.

All lanes:

Immunoprecipitation - Anti-MTFR1 antibody (ab242093)

Predicted band size: 37 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human MTFR1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q15390

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p>8 - 15 μl/mg lysate</p>" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Product details

ab242093 has not performed satisfactorily when used for WB of MTFR1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of MTFR1.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antibody was affinity purified using an epitope specific to MTFR1 immobilized on solid support.
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MTFR1 also known as mitochondrial fission regulator 1 is a protein involved in mitochondrial dynamics. It has a molecular mass of approximately 32 kDa. This protein is predominantly expressed in tissues with high metabolic demand such as muscle and liver. MTFR1 plays a role in mitochondrial fission impacting how mitochondria divide and distribute within cells. The protein's regulation of mitochondrial shape and distribution affects energy supply and cellular homeostasis.
Biological function summary

The regulation of mitochondrial fission by MTFR1 is important for energy production and cell signaling. It is often found as part of a larger protein complex that works together to execute mitochondrial fission. This function ensures that cells have the necessary energy supply and can properly react to metabolic changes. The balance between mitochondrial fission and fusion maintains cellular functions and supports cellular adaptation to metabolic stress.

Pathways

MTFR1 integrates into pathways involved in energy homeostasis and mitochondrial quality control. It plays a role in the mitochondrial fission pathway interacting with proteins like DRP1 (Dynamin-related protein 1) which is important for driving the division of mitochondria. MTFR1 also influences pathways affecting metabolic control linking mitochondrial dynamics to broader cellular functions and energy balance.

MTFR1 dysregulation has associations with neurodegenerative diseases like Parkinson's disease and metabolic disorders such as diabetes. MTFR1’s interaction with DRP1 and other fission proteins influences mitochondrial function and may lead to mitochondrial dysfunction contributing to the pathogenesis of these conditions. Understanding how MTFR1 and its network influence these diseases may offer insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity).
See full target information MTFR1
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