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AB240569

Anti-MTMR1 antibody

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(2 Publications)

Rabbit Polyclonal MTMR1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MTMR1 aa 600-700.

View Alternative Names

Phosphatidylinositol-3-phosphate phosphatase MTMR1, Myotubularin-related protein 1, MTMR1

2 Images
Immunoprecipitation - Anti-MTMR1 antibody (AB240569)
  • IP

Supplier Data

Immunoprecipitation - Anti-MTMR1 antibody (AB240569)

MTMR1 was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN lysis buffer. For western blotting, ab240569 was used at 0.4 μg/ml.

Lane 1 : ab240569 used for IP at 6 μg per reaction.
Lane 2 : Control IgG.

Detection : Chemiluminescence with an exposure time of 3 minutes.

All lanes:

Immunoprecipitation - Anti-MTMR1 antibody (ab240569)

Predicted band size: 75 kDa

false

Western blot - Anti-MTMR1 antibody (AB240569)
  • WB

Supplier Data

Western blot - Anti-MTMR1 antibody (AB240569)

Lysates prepared using NETN lysis buffer.

All lanes:

Western blot - Anti-MTMR1 antibody (ab240569) at 0.1 µg/mL

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Predicted band size: 75 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human MTMR1 aa 600-700. The exact immunogen used to generate this antibody is proprietary information.

Q13613

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab240569 was affinity purified using an epitope specific to MTMR1 immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MTMR1 also known as Myotubularin-related protein 1 belongs to the myotubularin family of phosphatidylinositol (PI) phosphatases. It plays a role in regulating phosphoinositide levels. The protein has a molecular mass of approximately 72 kDa. Scientists have found its expression in various tissues including skeletal muscle and the nervous system. MTMR1 is important for cellular homeostasis by modulating lipid signaling pathways.
Biological function summary

The protein functions as a phosphatase that removes phosphate groups from phosphatidylinositol 3-phosphate and phosphatidylinositol 35-bisphosphate. It does not work alone but as part of complexes that include other proteins from the same family. This collaboration allows for regulating PI levels which are involved in membrane trafficking and signal transduction. Its activity impacts cellular processes like endocytosis and autophagy which are important for cell maintenance and survival.

Pathways

MTMR1 is involved in pathways that include lipid signaling and autophagy. It particularly affects the PI3K-Akt signaling pathway which is important for controlling cell growth and apoptosis. MTMR1 can interact with other members of the myotubularin family like MTMR2 to execute its functions in these pathways. The interconnected work of these proteins ensures the correct functioning of signal transduction and cellular homeostasis.

MTMR1 has connections with muscular and neurological diseases. Particularly its dysfunction has been noted in types of muscular dystrophy. Researchers have linked its activity with proteins such as MTMR13 showing combined roles in disease mechanisms especially those affecting muscle tissue. Studies continue to explore these associations to understand better and manage related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed : 11733541, PubMed : 27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed : 27018598).
See full target information MTMR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature 637:983-990 PubMed39663456

2024

In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor.

Applications

Unspecified application

Species

Unspecified reactive species

Huaipeng Xing,Remus R E Rosenkranz,Piere Rodriguez-Aliaga,Ting-Ting Lee,Tomáš Majtner,Stefanie Böhm,Beata Turoňová,Judith Frydman,Martin Beck

Cell reports 33:108264 PubMed33053349

2020

Activation of the CARD8 Inflammasome Requires a Disordered Region.

Applications

Unspecified application

Species

Unspecified reactive species

Ashley J Chui,Andrew R Griswold,Cornelius Y Taabazuing,Elizabeth L Orth,Kuo Gai,Sahana D Rao,Daniel P Ball,Jeffrey C Hsiao,Daniel A Bachovchin
View all publications
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Product promise

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