AB75316

Anti-MTTP/MTP antibody

Name: Anti-MTTP/MTP antibody (ab75316) | Abcam
Brand: Abcam Limited
SKU: AB75316
Price: 545 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(16 Publications)

Rabbit Polyclonal MTTP/MTP antibody. Suitable for WB and reacts with Mouse samples. Cited in 16 publications.

View Alternative Names

Mtp, Mttp, Microsomal triglyceride transfer protein large subunit

1 Images

Unknown

Western blot - Anti-MTTP/MTP antibody (AB75316)

All lanes:

Western blot - Anti-MTTP/MTP antibody (ab75316) at 1/500 dilution

All lanes:

Liver (Mouse) Tissue Lysate at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

Predicted band size: 99 kDa

Observed band size: 40 kDa,99 kDa

true

Exposure time: 1min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Reactivity with human samples appears to be lot-dependent. A user reported strong western blot reactivity with a mouse cell lysate but none with a human HepG2 lysate.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/2000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed : 15897609, PubMed : 16478722, PubMed : 18502767, PubMed : 33168624). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed : 10713055, PubMed : 17635917, PubMed : 18502767, PubMed : 33168624, PubMed : 9502759). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (PubMed : 18502767).. Isoform 2. Critical for the development of natural killer T (NKT) cells (PubMed : 17312007). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed : 17635917).

See full target information Mttp

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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

Biological procedures online 27:14 PubMed40229695

2025

Differences in Fatty Acid Metabolism between MCDD and HFD Induced Metabolic Dysfunction-associated Fatty Liver Disease Model Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Xuan Wang,Xin-Zhu Liu,Zhen Guo,Hui-Lin Zhang,Li Qi,Jia Liu,Ping Liu,Guo-Xiang Xie,Xiao-Ning Wang

Physiological reports 12:e15929 PubMed38307709

2024

Endurance exercise upregulates mtp expression in aged Drosophila to ameliorate age-related diastolic dysfunction and extend lifespan.

Applications

Unspecified application

Species

Unspecified reactive species

Tianhang Peng,Meng Ding,Hanhui Yan,Ping Zhang,Rui Tian,Yin Guo,Lan Zheng

Neuro-oncology 25:471-481 PubMed36044040

2022

In vivo functional characterization of EGFR variants identifies novel drivers of glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Kwanha Yu,Kathleen Kong,Brittney Lozzi,Estefania Luna-Figueroa,Alexis Cervantes,Rachel Curry,Carrie A Mohila,Ganesh Rao,Ali Jalali,Gordon B Mills,Kenneth L Scott,Benjamin Deneen

Liver international : official journal of the International Association for the Study of the Liver 42:1793-1802 PubMed35460172

2022

The DEAD-box helicase DDX3x ameliorates non-alcoholic fatty liver disease via mTORC1 signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Peihao Liu,Yuwei Zhang,Chenxi Tang,Li Cen,Yishu Chen,Sha Li,Xueyang Chen,Mengli Yu,Jie Zhang,Xiaofen Zhang,Hang Zeng,Chengfu Xu,Chaohui Yu

The Journal of clinical investigation 132: PubMed34855620

2021

Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Neha Bhat,Anand Narayanan,Mohsen Fathzadeh,Mario Kahn,Dongyan Zhang,Leigh Goedeke,Arpita Neogi,Rebecca L Cardone,Richard G Kibbey,Carlos Fernandez-Hernando,Henry N Ginsberg,Dhanpat Jain,Gerald I Shulman,Arya Mani

Cells 9: PubMed32977490

2020

The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging.

Applications

Unspecified application

Species

Unspecified reactive species

Paloma Gallego,Beatriz Castejón-Vega,José A Del Campo,Mario D Cordero

Science advances 6: PubMed32917715

2020

Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Zhou,Mingming Zhen,Meilan Yu,Xue Li,Tong Yu,Jingchao Liu,Wang Jia,Shuai Liu,Lei Li,Jie Li,Zihao Sun,Zhongpu Zhao,Xinyao Wang,Xiaoyan Zhang,Chunru Wang,Chunli Bai

Journal of biochemical and molecular toxicology 34:e22497 PubMed32220030

2020

Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4α-dependent very low-density lipoprotein.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Song,Wangfei Wu,Liang Sheng,Bijie Jiang,Xiao Li,Keshu Cai

Biochimica et biophysica acta. Molecular and cell biology of lipids 1864:213-223 PubMed30553054

2018

High-fat diet induces aberrant hepatic lipid secretion in blunt snout bream by activating endoplasmic reticulum stress-associated IRE1/XBP1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiu-Fei Cao,Yong-Jun Dai,Ming-Yang Liu,Xiang-Yang Yuan,Cong-Cong Wang,Yang-Yang Huang,Wen-Bin Liu,Guang-Zhen Jiang

Cell metabolism 27:843-853.e6 PubMed29617643

2018

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Luo,Ming Jiang,Guili Lian,Qing Liu,Meng Shi,Terytty Yang Li,Lintao Song,Jing Ye,Ying He,Luming Yao,Cixiong Zhang,Zhi-Zhong Lin,Chen-Song Zhang,Tong-Jin Zhao,Wei-Ping Jia,Peng Li,Shu-Yong Lin,Sheng-Cai Lin

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MTTP/MTP antibody

Western blot - Anti-MTTP/MTP antibody (AB75316)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (16)

Product promise