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AB89492

Anti-MUC1 antibody [BC-2]

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(4 Publications)

Mouse Monoclonal MUC1 antibody. Suitable for IHC-P, IHC-Fr and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Tissue preparation containing MUC1 protein.

View Alternative Names

CD227, PUM, MUC1, Mucin-1, MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, PEMT, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin, CA 15-3, KL-6, PEM, EMA

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MUC1 antibody [BC-2] (AB89492)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MUC1 antibody [BC-2] (AB89492)

IHC image of MUC1 staining in human pancreas adenocarcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab89492, 5μg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

BC-2

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-Fr, IHC-P

applications

Immunogen

Tissue preparation containing MUC1 protein. The exact immunogen used to generate this antibody is proprietary information.

P15941

Epitope

Reacts with a 5 amino acid epitope of the MUC1 core protein which is less affective for glycosilation than the epitopes detected by other MUC1 antibodies.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.5 Preservative: 0.02% Sodium azide Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
See full target information MUC1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Medicine 103:e39296 PubMed39151507

2024

Pancreatic head carcinoma derived from the dorsal pancreas is more likely to metastasize early than from the ventral pancreas through microvascular invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Gao,Yuhang Shen,Jun Dong,Yang Zhou,Chunfu Zhu,Qiang Yu,Xihu Qin

Biomedical reports 14:19 PubMed33335725

2020

Luteolin alters MUC1 extracellular domain, sT antigen, ADAM-17, IL-8, IL-10 and NF-κB expression in -infected gastric cancer CRL-1739 cells: A preliminary study.

Applications

Unspecified application

Species

Unspecified reactive species

Iwona Radziejewska,Małgorzata Borzym-Kluczyk,Katarzyna Leszczyńska

Advances in medical sciences 63:205-211 PubMed29197783

2017

Lotus tetragonolobus and Maackia amurensis lectins influence phospho-IκBα, IL-8, Lewis b and H type 1 glycoforms levels in H. pylori infected CRL-1739 gastric cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Iwona Radziejewska,Małgorzata Borzym-Kluczyk,Katarzyna Leszczyńska,Joanna Wosek,Anna Bielawska

Immunology and cell biology 67 ( Pt 3):183-95 PubMed2477330

1989

Monoclonal antibodies reactive with mucin expressed in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

P X Xing,J J Tjandra,S A Stacker,J G Teh,C H Thompson,P J McLaughlin,I F McKenzie
View all publications
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Product promise

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