JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB121014

Anti-Muc19 antibody

Be the first to review this product! Submit a review

|

(5 Publications)

Goat Polyclonal MUC19 antibody. Suitable for ICC/IF and reacts with Mouse samples. Cited in 5 publications.

View Alternative Names

Mucin-19, MUC-19, Gel-forming secreted mucin-19, Sublingual apomucin, Muc19

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Muc19 antibody (AB121014)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Muc19 antibody (AB121014)

ab121014 (1.8ug/ml) staining cells of the sublingual salivary gland (SLG) in mouse, but not any cells of the submandibular salivary gland (SMG).

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1.8 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Muc19 also known by the alternate name of human mucin 19 is a large glycoprotein with a mass of approximately 1.5 MDa. This protein gets expressed in specific epithelial tissues mainly in the submandibular glands and the respiratory tract. Muc19 contributes to the formation of mucus a critical component for the proper functioning of these tissues. The protein structure of Muc19 allows for its ability to interact with other mucins creating a dense and protective gel-like layer.
Biological function summary

Muc19 functions as an essential part of the mucosal barrier offering protection against pathogens and mechanical damage. It incorporates into complex structures with other mucins including MUC5B and MUC2 creating the viscoelastic properties of mucus that allow for trapping particles and facilitating their removal. The role of Muc19 in mucus production and its gel-forming ability ensure the maintenance of tissue hydration and the smooth functioning of the epithelial surfaces.

Pathways

Muc19 plays a role in the mucosal immunity and inflammation pathways. The interaction with other proteins like TFF1 and TFF3 further supports the maintenance and repair of the epithelial cell surface. In the immune response Muc19 facilitates the entrapment of pathogens serving as an initial defense against infections. By modulating the inflammatory response it helps maintain the balance in epithelial homeostasis.

Disruptions in the function or expression of Muc19 have been linked to respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. In these conditions altered Muc19 expression or glycosylation patterns can lead to thicker mucus impairing respiratory function. The protein shows interactions with other disease-related proteins including CFTR in cystic fibrosis where it affects ion transport and hydration of mucus. Studies of these interactions offer insights into potential therapeutic targets for treating mucin-related disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May function in ocular mucus homeostasis.
See full target information Muc19
style
left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Psychopharmacology 242:763-781 PubMed39903245

2025

Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Bryan D McElroy,Chen Li,Nicholas S McCloskey,Amber R Alberici,Lynn G Kirby

PloS one 16:e0245607 PubMed33465144

2021

Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.

Applications

Unspecified application

Species

Unspecified reactive species

Akihiko Kameyama,Risa Nishijima,Kimi Yamakoshi

Pathogens (Basel, Switzerland) 9: PubMed32899224

2020

Human Metapneumovirus Induces Mucin 19 Which Contributes to Viral Pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Kaitlin McBride,Ma Del Rocio Banos-Lara,Nagarjuna R Cheemarla,Antonieta Guerrero-Plata

Cell reports 30:4250-4265.e6 PubMed32209482

2020

Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Allison M Greaney,Taylor S Adams,Micha Sam Brickman Raredon,Elise Gubbins,Jonas C Schupp,Alexander J Engler,Mahboobe Ghaedi,Yifan Yuan,Naftali Kaminski,Laura E Niklason

Nature communications 11:991 PubMed32080185

2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha D Praktiknjo,Benedikt Obermayer,Qionghua Zhu,Liang Fang,Haiyue Liu,Hazel Quinn,Marlon Stoeckius,Christine Kocks,Walter Birchmeier,Nikolaus Rajewsky
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB245014

Anti-Tissue kallikrein antibody [EPR21764-154] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-Tissue kallikrein antibody [EPR21764-154] - BSA and Azide free (Detector) (AB245014)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Reagents, Controls & Accessories

AB7481

Normal Goat Serum

Immunohistochemistry (Frozen sections) - Normal Goat Serum (AB7481)

  • 5
  • 3
Primary Antibodies

AB74504

Anti-ZDHHC9 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZDHHC9 antibody (AB74504)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com