Polyclonal antibodies

Polyclonal antibodies are harvested from the serum of immunized animals and are valued for their ability to recognize multiple epitopes on any one antigen. This multi-target recognition makes them especially useful in research applications where high sensitivity is required, such as in detecting proteins expressed at low levels or in complex mixtures.

Rabbit polyclonal antibodies

Derived from rabbits, these antibodies are widely used in biomedical research due to their high sensitivity, broad epitope recognition, and versatility across applications, making them suitable for detecting a wide range of antigens in complex samples.

Chicken polyclonal antibodies

Chicken-derived polyclonals are valuable tools if you are looking for reduced cross-reactivity as they don’t bind to mammalian Fc receptors. This makes them an ideal choice when working on human, mouse or rat samples due to background noise is minimized.

Goat polyclonal antibodies

Goat antibodies are particularly useful for multiplexing where you want to use multiple antibodies simultaneously. They can easily be used alongside other commonly used types of antibodies such as mouse and rabbit antibodies. As goats are evolutionary distant from the most used sample sources (mouse, rat, human), they offer the additional advantage of reduced background noise from non-specific binding.

How are polyclonal antibodies produced?

Polyclonal antibody production typically starts with immunizing an animal with the target antigen to stimulate an immune response, involving the production of antigen-specific antibodies by the animal's B cells (Fig. 1). Immunizations of the same antigen are repeated at intervals of several weeks to increase the number and affinity of antigen-specific antibodies within the animal. The resulting immune-sera (a blood portion containing the antibodies) can be used in its crude form, or the antibodies can be isolated by affinity purification.

^{Figure 1. A typical process of polyclonal antibody production.}

Multiclonal antibodies

Multiclonal antibodies can be used as an alternative to traditional polyclonal antibodies. Similarly to polyclonal antibodies, they bind to multiple epitopes on the same target protein but also offer the same specificity and reproducibility benefits as recombinant monoclonal antibodies.

How are multiclonal antibodies produced?

Our multiclonal antibodies are designed to combine the broad epitope recognition ability of polyclonals with the reproducibility closer to that of monoclonal antibodies. Each multiclonal batch is engineered from a blend of monoclonal antibodies that target different epitopes on the same antigen, providing both high specificity and enhanced batch-to-batch consistency.