AB9880

Anti-Mumps nucleoprotein antibody [7B10]

Name: Anti-Mumps nucleoprotein antibody [7B10] (ab9880) | Abcam
Brand: Abcam Limited
SKU: AB9880
Price: 510 USD
Availability: InStock

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(14 Publications)

Mouse Monoclonal NCAP antibody. Suitable for I-ELISA, WB and reacts with Mumps orthorubulavirus, Recombinant full length protein - Mumps orthorubulavirus samples. Cited in 14 publications.

View Alternative Names

NP, Nucleocapsid protein, Nucleoprotein

1 Images

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Western blot - Anti-Mumps nucleoprotein antibody [7B10] (AB9880)

Immunoblot of yeast-derived mumps NP using monoclonal antibody 7B10.
Lane 1 - prestained standard proteins
Lane 2 - mumps NP
Antibody 7B10 at a concentration of 0.5 μg/ml.

All lanes:

Western blot - Anti-Mumps nucleoprotein antibody [7B10] (ab9880)

Predicted band size: 66 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

7B10

Isotype

IgG2a

Light chain type

unknown

Carrier free

Reacts with

Mumps orthorubulavirus

Applications

I-ELISA, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IELISA" : {"fullname" : "Indirect ELISA", "shortname":"I-ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mumps orthorubulavirus": { "IELISA-species-checked": "guaranteed", "IELISA-species-dilution-info": "1/1000 - 1/10000", "IELISA-species-notes": "<p></p>", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant full length protein - Mumps orthorubulavirus": { "IELISA-species-checked": "notRecommended", "IELISA-species-dilution-info": "", "IELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }

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Product details

This product was changed from ascites to tissue culture supernatant on 28/11/2017. Lot numbers higher than GR293636-4 and GR137414-5 will be from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.1% Sodium azide

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The mumps nucleoprotein sometimes referred to as N protein plays an important role in the replication and transcription of the mumps virus acting as a structural element in the formation of viral ribonucleoprotein (RNP) complexes. The nucleoprotein is a large protein with a molecular mass of approximately 60 kDa and is expressed in cells that are infected by the mumps virus. It facilitates encapsidation of viral RNA and ensures the stability of the viral genome which is essential for virus survival and propagation.

Biological function summary

The mumps nucleoprotein functions as a part of the mumps virus replication complex. It interacts with other viral proteins such as the phosphoprotein (P protein) and the large protein (L protein) to initiate and regulate the replication of viral RNA. These interactions are critical for the stabilization of the entire complex ensuring the efficient production of new viral particles within host cells. The nucleoprotein is primarily located in the cytoplasm of infected cells where it associates with newly synthesized viral RNA strands.

Pathways

The mumps nucleoprotein is involved in the viral replication and transcription pathways specific to the mumps virus. These pathways facilitate viral spread and infection contributing to the virulence of the virus. The nucleoprotein works closely with L and P proteins which serve vital roles in the RNA polymerase complex guiding the synthesis of viral RNA. These interactions are part of the broader negative-strand RNA virus replication pathway shared by other viruses in the Paramyxoviridae family.

The mumps nucleoprotein is directly associated with the mumps disease a contagious viral infection that can lead to severe complications such as encephalitis and orchitis. Antibodies targeting the nucleoprotein can help in diagnosing mumps infections. The nucleoprotein also has implications in mumps-related complications where it interacts with immune system components. Research into this protein helps in understanding the immunological response to the mumps virus potentially informing vaccine development and antiviral therapies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Mumps nucleoprotein

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Journal of microbiology (Seoul, Korea) 63:e.2409007 PubMed39895072

2025

Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus.

Applications

Unspecified application

Species

Unspecified reactive species

Jueun Oh,Hayeon Kim,Jihye Lee,Suhyun Kim,Seyun Shin,Young-Eui Kim,Sehee Park,SangJoon Lee

The Journal of experimental medicine 219: PubMed35442417

2022

Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher J A Duncan,Morten K Skouboe,Sophie Howarth,Anne K Hollensen,Rui Chen,Malene L Børresen,Benjamin J Thompson,Jarmila Stremenova Spegarova,Catherine F Hatton,Frederik F Stæger,Mette K Andersen,John Whittaker,Søren R Paludan,Sofie E Jørgensen,Martin K Thomsen,Jacob G Mikkelsen,Carsten Heilmann,Daniela Buhas,Nina F Øbro,Jakob T Bay,Hanne V Marquart,M Teresa de la Morena,Joseph A Klejka,Matthew Hirschfeld,Line Borgwardt,Isabel Forss,Tania Masmas,Anja Poulsen,Francisco Noya,Guy Rouleau,Torben Hansen,Sirui Zhou,Anders Albrechtsen,Reza Alizadehfar,Eric J Allenspach,Sophie Hambleton,Trine H Mogensen

Frontiers in immunology 12:796065 PubMed35003119

2021

Rubella Virus Infected Macrophages and Neutrophils Define Patterns of Granulomatous Inflammation in Inborn and Acquired Errors of Immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Ludmila Perelygina,Raeesa Faisthalab,Emily Abernathy,Min-Hsin Chen,LiJuan Hao,Lionel Bercovitch,Diana K Bayer,Lenora M Noroski,Michael T Lam,Maria Pia Cicalese,Waleed Al-Herz,Arti Nanda,Joud Hajjar,Koen Vanden Driessche,Shari Schroven,Julie Leysen,Misha Rosenbach,Philipp Peters,Johannes Raedler,Michael H Albert,Roshini S Abraham,Hemalatha G Rangarjan,David Buchbinder,Lisa Kobrynski,Anne Pham-Huy,Julie Dhossche,Charlotte Cunningham Rundles,Anna K Meyer,Amy Theos,T Prescott Atkinson,Amy Musiek,Mehdi Adeli,Ute Derichs,Christoph Walz,Renate Krüger,Horst von Bernuth,Christoph Klein,Joseph Icenogle,Fabian Hauck,Kathleen E Sullivan

Frontiers in immunology 12:580454 PubMed33679733

2021

Characterization of an Antiviral Component in Human Seminal Plasma.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Chen,Wenjing Zhang,Maolei Gong,Fei Wang,Han Wu,Weihua Liu,Yunxiao Gao,Baoxing Liu,Song Chen,Wei Lu,Xiaoqin Yu,Aijie Liu,Ruiqin Han,Yongmei Chen,Daishu Han

Virologica Sinica 36:521-536 PubMed33284397

2020

Development of Improved Mumps Vaccine Candidates by Mutating Viral mRNA Cap Methyltransferase Sites in the Large Polymerase Protein.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoqiang Hao,Yilong Wang,Mengying Zhu,Dongming Zhou,Rongxian Liu,Bin Wang,Yao-Wei Huang,Zhengyan Zhao

Vaccines 8: PubMed32325874

2020

Protective Malaria Vaccine in Mice Based on the Circumsporozoite Protein Fused with the Mumps Nucleocapsid Protein.

Applications

Unspecified application

Species

Unspecified reactive species

Rodolfo F Marques,Alba Marina Gimenez,Eduardo Aliprandini,Janaina T Novais,Diego P Cury,Ii-Sei Watanabe,Mariana R Dominguez,Eduardo L V Silveira,Rogerio Amino,Irene S Soares

FASEB journal : official publication of the Federa 33:12528-12540 PubMed31450968

2019

Mumps virus infection disrupts blood-testis barrier through the induction of TNF-α in Sertoli cells.

Applications

Unspecified application

Species

Unspecified reactive species

Han Wu,Xing Jiang,Yunxiao Gao,Weihua Liu,Fei Wang,Maolei Gong,Ran Chen,Xiaoqin Yu,Wenjing Zhang,Bo Gao,Chengyi Song,Daishu Han

IEEE journal of solid-state circuits 53:2054-2064 PubMed30559530

2018

High-Density Redox Amplified Coulostatic Discharge-Based Biosensor Array.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander C Sun,Enrique Alvarez-Fontecilla,A G Venkatesh,Eliah Aronoff-Spencer,Drew A Hall

Scientific reports 7:43395 PubMed28262699

2017

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.

Applications

Unspecified application

Species

Unspecified reactive species

Michael K Lo,Robert Jordan,Aaron Arvey,Jawahar Sudhamsu,Punya Shrivastava-Ranjan,Anne L Hotard,Mike Flint,Laura K McMullan,Dustin Siegel,Michael O Clarke,Richard L Mackman,Hon C Hui,Michel Perron,Adrian S Ray,Tomas Cihlar,Stuart T Nichol,Christina F Spiropoulou

Vaccine 34:4166-4171 PubMed27372154

2016

Mumps-specific cross-neutralization by MMR vaccine-induced antibodies predicts protection against mumps virus infection.

Applications

Unspecified application

Species

Unspecified reactive species

Sigrid Gouma,Hinke I Ten Hulscher,Tessa M Schurink-van 't Klooster,Hester E de Melker,Greet J Boland,Patricia Kaaijk,Cécile A C M van Els,Marion P G Koopmans,Rob S van Binnendijk

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Mumps nucleoprotein antibody [7B10]

Western blot - Anti-Mumps nucleoprotein antibody [7B10] (AB9880)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (14)

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