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AB234798

Anti-Munc13-3 antibody

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(2 Publications)

Rabbit Polyclonal Munc13-3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Protein unc-13 homolog C aa 400-650.

View Alternative Names

Protein unc-13 homolog C, Munc13-3, UNC13C

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Munc13-3 antibody (AB234798)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Munc13-3 antibody (AB234798)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for Munc13-3 (green) using ab234798 at 1/100 dilution in ICC/IF, followed by Alexa Fluor® 488 conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Munc13-3 antibody (AB234798)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Munc13-3 antibody (AB234798)

Paraffin-embedded human testis tissue stained for Munc13-3 using ab234798 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Protein unc-13 homolog C aa 400-650. The exact immunogen used to generate this antibody is proprietary information.

Q8NB66

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Complementary Products

Primary Antibodies

AB307511

Anti-Munc13-1 antibody [EPR27022-47]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Anti-Munc13-1 antibody [EPR27022-47] (AB307511)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB97924

Anti-UNC13B antibody

Immunocytochemistry/ Immunofluorescence - Anti-UNC13B antibody (AB97924)

  • 0
  • 0
Primary Antibodies

AB234867

Anti-Use1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Use1 antibody (AB234867)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Munc13-3 also known as Unc-13 homolog C (UNC13C) is a protein involved in synaptic vesicle priming necessary for neurotransmitter release. It weighs approximately 230 kDa. Munc13-3 is expressed mainly in the brain specifically in regions such as the cerebellum. This protein plays a role in the efficiency and timing of synaptic transmission which is critical for normal neuronal communication.
Biological function summary

Munc13-3 acts in the presynaptic region where it functions as part of the synaptic vesicle release machinery. It forms a complex with other proteins like syntaxin Munc18 and RIM proteins to facilitate neurotransmitter release. By interacting with these molecules it helps prepare vesicles for fusion with the plasma membrane modulating synaptic strength and plasticity.

Pathways

Proteins involved in synaptic transmission and plasticity often associate with Munc13-3. One important pathway is the synaptic vesicle cycle where Munc13-3 works closely with synaptotagmin and SNARE proteins to regulate vesicle docking and fusion. Another relevant pathway is the calcium signaling pathway which triggers vesicle release through Munc13-3's interactions with other calcium-sensing proteins ensuring precise neurotransmitter release in response to calcium influx.

Links between Munc13-3 and neurological conditions like autism spectrum disorders and epilepsy are evident. Munc13-3 influences synaptic function and alterations in its expression or function can disrupt normal synaptic activity. Related proteins are Munc13-1 and STXBP1 which interact with Munc13-3 in these conditions suggesting possible therapeutic targets for modulating synaptic communication issues seen in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).
See full target information Protein unc-13 homolog C
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 15:2549-2560 PubMed38577587

2024

Ribosomal protein L22 like 1: a promising biomarker for lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yahua Wu,Na Yao,Bin Du,Yingjiao Zhu,Xiaohui Ji,Chengliu Lv,Jinhuo Lai

World journal of surgical oncology 19:75 PubMed33715625

2021

Circ-KIAA0907 inhibits the progression of oral squamous cell carcinoma by regulating the miR-96-5p/UNC13C axis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjie Dong,Lei Zhao,Shiyang Zhang,Shijie Zhang,Hongyun Si
View all publications
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Product promise

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