Mouse Monoclonal MURF1 antibody. Suitable for Flow Cyt, IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TRIM63 aa 250-350.
Images
![Flow Cytometry - Anti-MURF1 antibody [7B8E1] (AB201941), expandable thumbnail](https://content.abcam.com/products/images/murf1-antibody-7b8e1-ab201941--flow-cytometry-img121876.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - Anti-MURF1 antibody [7B8E1] (AB201941)")
![Immunocytochemistry/ Immunofluorescence - Anti-MURF1 antibody [7B8E1] (AB201941), expandable thumbnail](https://content.abcam.com/products/images/murf1-antibody-7b8e1-ab201941--immunocytochemistry-immunofluorescence-img127882.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry/ Immunofluorescence - Anti-MURF1 antibody [7B8E1] (AB201941)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (AB201941), expandable thumbnail](https://content.abcam.com/products/images/murf1-antibody-7b8e1-ab201941--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img48630.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (AB201941)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (AB201941), expandable thumbnail](https://content.abcam.com/products/images/murf1-antibody-7b8e1-ab201941--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img134858.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (AB201941)")
Publications
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- Saudi medical journal 44:355-3622023The histopathological effects of sleep disorders on striated muscle in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesİlkay Çinar,Muhammed Bozoğlan,Kürşad Aytekin,Deniz Esenyel,Cem Zeki EsenyelPubMed 37062544
- Physiological reports 10:e154222022Hydrogen sulfide mitigates skeletal muscle mitophagy-led tissue remodeling via epigenetic regulation of the gene writer and eraser function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMahavir Singh,Sathnur Pushpakumar,Yuting Zheng,Rubens P Homme,Irina Smolenkova,Sri Prakash L Mokshagundam,Suresh C TyagiPubMed 35986494
- Journal of cellular and molecular medicine 25:9724-97392021Sepsis induces muscle atrophy by inhibiting proliferation and promoting apoptosis via PLK1-AKT signalling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing-Ya Cao,Zhen Wang,Tao Yu,Yuan Zhang,Zhong-Han Wang,Zi-Meng Lu,Wei-Hua Lu,Jian-Bo YuPubMed 34514712
- Journal of cellular and molecular medicine 25:1493-15062021Formononetin ameliorates muscle atrophy by regulating myostatin-mediated PI3K/Akt/FoxO3a pathway and satellite cell function in chronic kidney disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLingyu Liu,Rong Hu,Haiyan You,Jingjing Li,Yangyang Liu,Qiang Li,Xiaohui Wu,Jiawen Huang,Xiangsheng Cai,Mingqing Wang,Lianbo WeiPubMed 33405354
- American journal of physiology. Endocrinology and 312:E495-E5072017Forkhead box O3 plays a role in skeletal muscle atrophy through expression of E3 ubiquitin ligases MuRF-1 and atrogin-1 in Cushing's syndrome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSeol-Hee Kang et. al.PubMed 28246104
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Synthetic Peptide within Human TRIM63 aa 250-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q969Q1
Reactivity data
Select an application| Flow Cyt | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Predicted | Predicted | Predicted |
| Rat | Predicted | Predicted | Predicted |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200 - 1/400 | Notes ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200 - 1/1000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200 - 1/1000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Alternative names
IRF, MURF1, RNF28, SMRZ, TRIM63, E3 ubiquitin-protein ligase TRIM63, Iris RING finger protein, Muscle-specific RING finger protein 1, RING finger protein 28, RING-type E3 ubiquitin transferase TRIM63, Striated muscle RING zinc finger protein, Tripartite motif-containing protein 63, MuRF-1, MuRF1
Recommended products
Mouse Monoclonal MURF1 antibody. Suitable for Flow Cyt, IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TRIM63 aa 250-350.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Synthetic Peptide within Human TRIM63 aa 250-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q969Q1
- Clone number
- 7B8E1
- Purification technique
- Affinity purification Protein G
- Concentration
- Purification notes
Purified from tissue culture supernatant.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
4 product images
![Flow Cytometry - Anti-MURF1 antibody [7B8E1] (ab201941), expandable thumbnail](https://content.abcam.com/products/images/murf1-antibody-7b8e1-ab201941--flow-cytometry-img121876.jpg "Flow Cytometry - Anti-MURF1 antibody [7B8E1] (ab201941)")
Flow Cytometry - Anti-MURF1 antibody [7B8E1] (ab201941)
Flow cytometric analysis of HeLa cells labeling MURF1 with ab201941 at 1/200 dilution (green) compared to a negative control (red).
![Immunocytochemistry/ Immunofluorescence - Anti-MURF1 antibody [7B8E1] (ab201941), expandable thumbnail](https://content.abcam.com/products/images/murf1-antibody-7b8e1-ab201941--immunocytochemistry-immunofluorescence-img127882.jpg "Immunocytochemistry/ Immunofluorescence - Anti-MURF1 antibody [7B8E1] (ab201941)")
Immunocytochemistry/ Immunofluorescence - Anti-MURF1 antibody [7B8E1] (ab201941)
Immunofluorescent analysis of HeLa cells labeling MURF1 with ab201941 at 1/200 dilution. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (ab201941), expandable thumbnail](https://content.abcam.com/products/images/murf1-antibody-7b8e1-ab201941--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img48630.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (ab201941)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (ab201941)
Immunohistochemical analysis of paraffin-embedded Human rectum cancer tissue labeling MURF1 with ab201941 at 1/200 dilution, with DAB staining.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (ab201941), expandable thumbnail](https://content.abcam.com/products/images/murf1-antibody-7b8e1-ab201941--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img134858.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (ab201941)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody [7B8E1] (ab201941)
Immunohistochemical analysis of paraffin-embedded Human muscle tissue labeling MURF1 with ab201941 at 1/200 dilution, with DAB staining.
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