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AB77098

Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 antibody

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(6 Publications)

Goat Polyclonal Muscarinic Acetylcholine Receptor 1/CHRM1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human CHRM1 aa 400 to C-terminus.

View Alternative Names

Muscarinic acetylcholine receptor M1, CHRM1

1 Images
Western blot - Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 antibody (AB77098)
  • WB

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Western blot - Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 antibody (AB77098)

All lanes:

Western blot - Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 antibody (ab77098) at 0.3 µg/mL

All lanes:

human brain lysate (in RIPA buffer) at 35 µg

Predicted band size: 51 kDa

Observed band size: 48 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CHRM1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P11229

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab77098 is purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Muscarinic Acetylcholine Receptor 1 (CHRM1) is a G protein-coupled receptor that plays an important role in transmitting acetylcholine-mediated cholinergic signals. It also goes by the names 'M1 receptor' or 'muscarinic acetylcholine receptors'. The protein has a mass of approximately 51 kDa and is largely expressed in the central nervous system particularly in the cerebral cortex and hippocampus. Its activation leads to intracellular signaling cascades involving the modulation of ion channels and influencing cellular responses.
Biological function summary

CHRM1 participates in various neural functions by interacting with acetylcholine. It does not form part of a complex itself but has significant interactions with other proteins particularly in nerve cells influencing cognitive processes and memory. CHRM1 plays an essential role in modulating neurotransmission which affects neuronal excitability and synaptic plasticity contributing to learning and attention processes.

Pathways

CHRM1 is involved in the phosphoinositide pathway and modulation of the MAPK/ERK pathway. The receptor interacts with proteins like Gq and G11 family members during signal transduction. These pathways help mediate the cellular actions initiated by neurotransmitter binding therefore facilitating long-term potentiation and contributing to cognitive function and higher brain activities.

CHRM1 is associated with Alzheimer's disease and schizophrenia. Altered signaling or expression of this receptor often correlates with cognitive decline in Alzheimer's disease suggesting a significant role in neurodegenerative processes. In schizophrenia dysfunctional CHRM1 signaling may impact thought processes and behavioral symptoms. In these contexts CHRM1 is connected to proteins such as beta-amyloid in Alzheimer's and dopamine receptors in schizophrenia pointing to its relevance in these conditions' molecular pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
See full target information CHRM1
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed38719447

2024

Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Tsolias,Yuxin Zhou,Chromewell A Mojica,Mitali Sakharkar,Marianna Z Tsolias,Tara L Moore,Douglas L Rosene,Maria Medalla

Communications biology 7:3 PubMed38168628

2024

Activation of M1 cholinergic receptors in mouse somatosensory cortex enhances information processing and detection behaviour.

Applications

Unspecified application

Species

Unspecified reactive species

Wricha Mishra,Ehsan Kheradpezhouh,Ehsan Arabzadeh

Life science alliance 7: PubMed38056909

2023

IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium.

Applications

Unspecified application

Species

Unspecified reactive species

Sankhanil Saha,Harini Krishnan,Padinjat Raghu

Frontiers in neural circuits 15:795325 PubMed35087381

2022

Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Tsolias,Maria Medalla

Investigative ophthalmology & visual science 62:19 PubMed34546325

2021

Novel Insights Into Muscarinic and Purinergic Responses in Primary Cultures of Rat Lacrimal Gland Myoepithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Martin Dankis,Thomas Carlsson,Patrik Aronsson,Gunnar Tobin,Michael Winder

Basic & clinical pharmacology & toxicology 121:257-265 PubMed28437032

2017

Autonomic Receptor-mediated Regulation of Production and Release of Nitric Oxide in Normal and Malignant Human Urothelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Winder,Renata Vesela,Patrik Aronsson,Bhavik Patel,Thomas Carlsson
View all publications
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