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AB126619

Anti-MVK antibody [EPR6507]

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(4 Publications )

Rabbit Recombinant Monoclonal MVK antibody. Suitable for Flow Cyt (Intra), WB and reacts with Human samples. Cited in 4 publications.

View Alternative Names

Mevalonate kinase, MK, MVK

3 Images
Flow Cytometry (Intracellular) - Anti-MVK antibody [EPR6507] (AB126619)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - Anti-MVK antibody [EPR6507] (AB126619)

ab126619, at a 1/10 dilution, positively staining MVK in permeabilized HepG2 cells (red). A Rabbit IgG was used as negative control (green).

Western blot - Anti-MVK antibody [EPR6507] (AB126619)
  • WB

Unknown

Western blot - Anti-MVK antibody [EPR6507] (AB126619)

All lanes:

Western blot - Anti-MVK antibody [EPR6507] (ab126619) at 1/1000 dilution

Lane 1:

HepG2 cell lysate at 10 µg

Lane 2:

Jurkat cell lysate at 10 µg

Lane 3:

Caco-2 cell lysate at 10 µg

Lane 4:

Human fetal liver tissue lysate at 10 µg

Secondary

All lanes:

Standard HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 42 kDa

Observed band size: 42 kDa

false

OI-RD Scanning - Anti-MVK antibody [EPR6507] (AB126619)
  • OI-RD Scanning

Unknown

OI-RD Scanning - Anti-MVK antibody [EPR6507] (AB126619)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

  • Carrier free

    Anti-MVK antibody [EPR6507] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR6507

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

Flow Cyt (Intra), WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed : 11278915, PubMed : 18302342, PubMed : 9325256, PubMed : 9392419).
See full target information Mevalonate kinase

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 44:2906-2927 PubMed40195499

2025

The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Guo,Zhao-Feng Li,Dong-Yan Hu,Pei-Jun Li,Kai-Nian Wu,Hui-Hui Fan,Jie Deng,Hong-Mei Wu,Xiong Zhang,Jian-Hong Zhu

Cell death & disease 15:704 PubMed39349433

2024

Cholesterol inhibition enhances antitumor response of gilteritinib in lung cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chao-Yue Sun,Di Cao,Yue-Ning Wang,Nuo-Qing Weng,Qian-Nan Ren,Shuo-Cheng Wang,Mei-Yin Zhang,Shi-Juan Mai,Hui-Yun Wang

Molecular carcinogenesis 62:754-770 PubMed36920044

2023

Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Fengjiao He,Qiong Liu,Huan Liu,Qian Pei,Hong Zhu

Cancers 14: PubMed35565457

2022

Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins.

Applications

Unspecified application

Species

Unspecified reactive species

Charlie Buchou,Karine Laud-Duval,Wietske van der Ent,Sandrine Grossetête,Sakina Zaidi,Géraldine Gentric,Maxime Corbé,Kévin Müller,Elaine Del Nery,Didier Surdez,Olivier Delattre
View all publications

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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