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AB193422

Anti-Mycobacterium tuberculosis 16kDa antibody

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(1 Publication)

Rabbit Polyclonal Mycobacterium tuberculosis 16kDa antibody. Suitable for WB and reacts with Mycobacterium tuberculosis samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mycobacterium tuberculosis H37Rv mpt63.

View Alternative Names

Rv1926c, MTCY09F9.38, mpt63, Immunogenic protein MPT63, 16 kDa immunoprotective extracellular protein, Antigen MPT63

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mycobacterium tuberculosis

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Mycobacterium tuberculosis H37Rv mpt63.

P9WIP1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mycobacterium tuberculosis": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
>95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 16kDa protein also known as Acr or HspX is a well-characterized antigen of Mycobacterium tuberculosis. Its molecular weight is approximately 16 kDa. This protein expresses prominently during the latent phase of the bacterium within host cells. The 16kDa protein functions primarily as a chaperone ensuring proper protein folding and stabilization under stress conditions. It resides mainly in the cytoplasm of Mycobacterium tuberculosis and plays a role in the bacterial stress response.
Biological function summary

The function of the 16kDa protein ties closely to the bacterium's ability to persist within host tissues. The protein is part of the complex regulatory network involved in latency and survival contributing to immune evasion. It assists the bacterium in adapting to hypoxic nutrient-limited conditions common during chronic infection. Through these adaptations the 16kDa protein enhances the survival capabilities of Mycobacterium tuberculosis in the host environment.

Pathways

The activity of the 16kDa protein intersects with pathways involving stress response and dormancy regulation. It interacts with the DosR regulon a two-component system important for latency. Through this interaction the protein contributes to the Mycobacterium's response to low oxygen and nitric oxide levels. Additionally its relationship with other heat shock proteins strengthens its function in maintaining protein homeostasis under hostile conditions.

The 16kDa protein has strong links to tuberculosis a major infectious disease worldwide. Latent tuberculosis a state in which the bacteria persist in a dormant state heavily relies on proteins like the 16kDa protein for continued survival. Interactions with DosR and other latency-associated proteins make it an important target for studying latent tuberculosis mechanisms. Understanding the role of this protein in tuberculosis could lead to novel insights into therapeutic interventions targeting dormant infections.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information mpt63
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:752 PubMed38272918

2024

MHC-I upregulation safeguards neoplastic T cells in the skin against NK cell-mediated eradication in mycosis fungoides.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Tsan Chang,Pacôme Prompsy,Susanne Kimeswenger,Yi-Chien Tsai,Desislava Ignatova,Olesya Pavlova,Christoph Iselin,Lars E French,Mitchell P Levesque,François Kuonen,Malgorzata Bobrowicz,Patrick M Brunner,Steve Pascolo,Wolfram Hoetzenecker,Emmanuella Guenova
View all publications
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Product promise

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