Rabbit Polyclonal Mycobacterium tuberculosis 16kDa antibody. Suitable for WB and reacts with Mycobacterium tuberculosis samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mycobacterium tuberculosis H37Rv mpt63.
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
| WB | |
|---|---|
| Mycobacterium tuberculosis | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Mycobacterium tuberculosis | Dilution info 1/500.00000 - 1/2000.00000 | Notes - |
Select an associated product type
Mycobacterium tuberculosis 16kDa
Rv1926c, MTCY09F9.38, mpt63, Immunogenic protein MPT63, 16 kDa immunoprotective extracellular protein, Antigen MPT63
Rabbit Polyclonal Mycobacterium tuberculosis 16kDa antibody. Suitable for WB and reacts with Mycobacterium tuberculosis samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mycobacterium tuberculosis H37Rv mpt63.
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
>95%
The 16kDa protein also known as Acr or HspX is a well-characterized antigen of Mycobacterium tuberculosis. Its molecular weight is approximately 16 kDa. This protein expresses prominently during the latent phase of the bacterium within host cells. The 16kDa protein functions primarily as a chaperone ensuring proper protein folding and stabilization under stress conditions. It resides mainly in the cytoplasm of Mycobacterium tuberculosis and plays a role in the bacterial stress response.
The function of the 16kDa protein ties closely to the bacterium's ability to persist within host tissues. The protein is part of the complex regulatory network involved in latency and survival contributing to immune evasion. It assists the bacterium in adapting to hypoxic nutrient-limited conditions common during chronic infection. Through these adaptations the 16kDa protein enhances the survival capabilities of Mycobacterium tuberculosis in the host environment.
The activity of the 16kDa protein intersects with pathways involving stress response and dormancy regulation. It interacts with the DosR regulon a two-component system important for latency. Through this interaction the protein contributes to the Mycobacterium's response to low oxygen and nitric oxide levels. Additionally its relationship with other heat shock proteins strengthens its function in maintaining protein homeostasis under hostile conditions.
The 16kDa protein has strong links to tuberculosis a major infectious disease worldwide. Latent tuberculosis a state in which the bacteria persist in a dormant state heavily relies on proteins like the 16kDa protein for continued survival. Interactions with DosR and other latency-associated proteins make it an important target for studying latent tuberculosis mechanisms. Understanding the role of this protein in tuberculosis could lead to novel insights into therapeutic interventions targeting dormant infections.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com