Anti-Mycobacterium tuberculosis antibody (ab905) is a rabbit polyclonal antibody that is used to detect Mycobacterium tuberculosis in IHC-P.
- Over 20 publications
- Trusted since 2002
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- Nature communications 14:14302023A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLihua Qiang,Yong Zhang,Zehui Lei,Zhe Lu,Shasha Tan,Pupu Ge,Qiyao Chai,Mengyuan Zhao,Xinwen Zhang,Bingxi Li,Yu Pang,Lingqiang Zhang,Cui Hua Liu,Jing WangPubMed 36932056
- Heliyon 8:e123702022Utility of anti- antibody (ab905) for detection of mycobacterial antigens in formalin-fixed paraffin-embedded tissues from clinically and histologically suggestive extrapulmonary tuberculosis cases.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSamuel Ofori Addo,Afua Owusua Darkwah Abrahams,Gloria Ivy Mensah,Bernice Anane Mawuli,Lydia Mosi,Edwin Kwame Wiredu,Kennedy Kwasi AddoPubMed 36590545
- Molecular medicine reports 25:2022Estradiol inhibits autophagy of ‑infected 16HBE cells and controls the proliferation of intracellular .Applications:Unspecified applicationReactive species:Unspecified reactive speciesYiling Gan,Qianfang Hu,Anmao Li,Lei Gu,Shuliang GuoPubMed 35425995
- Advanced healthcare materials 11:e21026402022Development of a Highly Specific, Selective, and Sensitive Fluorescent Probe for Detection of Mycobacteria in Human Tissues.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSiddhi Gupta,Deepak Kumar Mishra,Mehak Zahoor Khan,Varsha Saini,Devashish Mehta,Sandeep Kumar,Aditya Yadav,Madhurima Mitra,Parul Rani,Mukesh Singh,Chayan Kanti Nandi,Prasenjit Das,Vineet Ahuja,Vinay Kumar Nandicoori,Avinash BajajPubMed 35038229
- Pathogens (Basel, Switzerland) 10:2021Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-Directed Therapies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRobert E Brown,Robert L HunterPubMed 34959527
- mBio 12:e01665212021Role of Premycofactocin Synthase in Growth, Microaerophilic Adaptation, and Metabolism of Mycobacterium tuberculosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGopinath Krishnamoorthy,Peggy Kaiser,Patricia Constant,Ulrike Abu Abed,Monika Schmid,Christian K Frese,Volker Brinkmann,Mamadou Daffé,Stefan H E KaufmannPubMed 34311585
- Cell host & microbe 29:594-606.e62021TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBenjamin H Gern,Kristin N Adams,Courtney R Plumlee,Caleb R Stoltzfus,Laila Shehata,Albanus O Moguche,Kathleen Busman-Sahay,Scott G Hansen,Michael K Axthelm,Louis J Picker,Jacob D Estes,Kevin B Urdahl,Michael Y GernerPubMed 33711270
- Cell host & microbe 29:68-82.e52020Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCourtney R Plumlee,Fergal J Duffy,Benjamin H Gern,Jared L Delahaye,Sara B Cohen,Caleb R Stoltzfus,Tige R Rustad,Scott G Hansen,Michael K Axthelm,Louis J Picker,John D Aitchison,David R Sherman,Vitaly V Ganusov,Michael Y Gerner,Daniel E Zak,Kevin B UrdahlPubMed 33142108
- Annals of clinical and laboratory science 50:429-4382020Morphoproteomics Identifies the Foamy Alveolar Macrophage as an M2 Phenotype with PD-L1 Expression in the Early Lesion of Post-Primary Tuberculosis: Implications for Host Immune Surveillance and Therapy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShen-An Hwang,Yasir Ali,Elena Fedotova,Robert L Hunter,Robert E BrownPubMed 32826237
- Disease models & mechanisms 13:2020FX11 limits growth and potentiates bactericidal activity of isoniazid through host-directed activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGopinath Krishnamoorthy et. al.PubMed 32034005
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.1% Sodium azide
Constituents: Carrier protein, PBS- Form
- Liquid
- Clonality
- Polyclonal
Reactivity data
Select an application| IHC-P | |
|---|---|
| Candida albicans | Not recommended |
| Escherichia coli | Not recommended |
| Mycobacterium tuberculosis | Tested |
| Salmonella typhimurium | Not recommended |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mycobacterium tuberculosis | Dilution info 1/500 | Notes ABC method. |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Candida albicans | Dilution info - | Notes ABC method. |
Species Escherichia coli | Dilution info - | Notes ABC method. |
Species Salmonella typhimurium | Dilution info - | Notes ABC method. |
Associated Products
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4 products for Alternative Product
Alternative names
M. tuberculosis
Recommended products
Anti-Mycobacterium tuberculosis antibody (ab905) is a rabbit polyclonal antibody that is used to detect Mycobacterium tuberculosis in IHC-P.
- Over 20 publications
- Trusted since 2002
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.1% Sodium azide
Constituents: Carrier protein, PBS- Form
- Liquid
- Clonality
- Polyclonal
- Purity
- IgG fraction
- Specificity
This antibody is reactive with other Mycobacteria species including: M. avium, M. phlei, and M. parafortuitum. This antibody has been reported not to be reactive with E. coli K12, Salmonella typhimurium, Pseudomonas aeruginosa, Streptococcus (group B), Candida albicans and Neisseria meningitides.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-Mycobacterium tuberculosis antibody (ab905) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P).
Trusted by the scientific community
Anti-Mycobacterium tuberculosis (ab905) was first used in a scientific publication in 2002 and has been cited over 20 times in peer-reviewed journals.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Mycobacterium tuberculosis sometimes referred to as M. tuberculosis is a pathogenic bacterial species in the Mycobacterium genus. It is the causative agent of tuberculosis (TB) in humans and has a relatively large cellular mass characterized by a thick and complex cell wall rich in mycolic acids. This bacterium expresses in the lungs where it primarily resides in pulmonary macrophages after inhalation. The robust cell wall serves as a barrier against phagocytosis and contributes to its resistance to many antimicrobial agents.
- Biological function summary
The bacteria stimulate a host immune response causing the formation of granulomas which are small nodular aggregations of immune cells. Mycobacterium tuberculosis employs several mechanisms to inhibit the lysosomal degradation processes in macrophages. It is part of a complex interplay involving the immune system which tries to control its spread. This interaction allows it to persist in a dormant state within the host making it difficult to eradicate completely and able to reactivate later.
- Pathways
Mycobacterium tuberculosis's survival and pathogenicity involve several critical biological processes. The bacteria actively dodge destruction through pathways that inhibit host cell apoptosis and modulate cytokine production. Specific proteins like the 6-kda early secretory antigen target (ESAT-6) and culture filtrate protein 10 (CFP-10) complexes play a vital role in these mechanisms manipulating host immune signaling pathways to facilitate prolonged infection.
- Associated diseases and disorders
Mycobacterium tuberculosis is directly associated with tuberculosis a disease that can affect different body organs but most often targets the lungs. The pathogen’s persistence mechanisms implicate it in chronic infections and proteins like Ag85 complex interact with host defenses to further complicate control of the disease. Another disorder linked to its infection is latent TB where the bacteria remain inactive but viable within the host posing ongoing public health challenges.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mycobacterium tuberculosis antibody (ab905)
Lung tissue stained with ab905 at 1/500.
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