AB905

Anti-Mycobacterium tuberculosis antibody

Name: Anti-Mycobacterium tuberculosis antibody (ab905) | Abcam
Brand: Abcam Limited
SKU: AB905
Price: 595 USD
Availability: InStock
Rating: 4 (2 reviews)

(2 Reviews)

(34 Publications)

Anti-Mycobacterium tuberculosis antibody (ab905) is a rabbit polyclonal antibody detecting Mycobacterium tuberculosis in IHC-P.

- Over 20 publications
- Trusted since 2002

View Alternative Names

M. tuberculosis

1 Images

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mycobacterium tuberculosis antibody (AB905)

Lung tissue stained with ab905 at 1/500.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mycobacterium tuberculosis

Applications

IHC-P

applications

Specificity

This antibody is reactive with other Mycobacteria species including: M. avium, M. phlei, and M. parafortuitum. This antibody has been reported not to be reactive with E. coli K12, Salmonella typhimurium, Pseudomonas aeruginosa, Streptococcus (group B), Candida albicans and Neisseria meningitides.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Candida albicans": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "ABC method." }, "Escherichia coli": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "ABC method." }, "Mycobacterium tuberculosis": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "ABC method." }, "Salmonella typhimurium": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "ABC method." } } }

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Product details

What is this antibody validated in?
Anti-Mycobacterium tuberculosis antibody (ab905) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P). Trusted by the scientific community
Anti-Mycobacterium tuberculosis (ab905) was first used in a scientific publication in 2002 and has been cited over 20 times in peer-reviewed journals.

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Properties and storage information

Form

Liquid

Purity

IgG fraction

Storage buffer

Preservative: 0.1% Sodium azide Constituents: Carrier protein, PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Mycobacterium tuberculosis sometimes referred to as M. tuberculosis is a pathogenic bacterial species in the Mycobacterium genus. It is the causative agent of tuberculosis (TB) in humans and has a relatively large cellular mass characterized by a thick and complex cell wall rich in mycolic acids. This bacterium expresses in the lungs where it primarily resides in pulmonary macrophages after inhalation. The robust cell wall serves as a barrier against phagocytosis and contributes to its resistance to many antimicrobial agents.

Biological function summary

The bacteria stimulate a host immune response causing the formation of granulomas which are small nodular aggregations of immune cells. Mycobacterium tuberculosis employs several mechanisms to inhibit the lysosomal degradation processes in macrophages. It is part of a complex interplay involving the immune system which tries to control its spread. This interaction allows it to persist in a dormant state within the host making it difficult to eradicate completely and able to reactivate later.

Pathways

Mycobacterium tuberculosis's survival and pathogenicity involve several critical biological processes. The bacteria actively dodge destruction through pathways that inhibit host cell apoptosis and modulate cytokine production. Specific proteins like the 6-kda early secretory antigen target (ESAT-6) and culture filtrate protein 10 (CFP-10) complexes play a vital role in these mechanisms manipulating host immune signaling pathways to facilitate prolonged infection.

Mycobacterium tuberculosis is directly associated with tuberculosis a disease that can affect different body organs but most often targets the lungs. The pathogen’s persistence mechanisms implicate it in chronic infections and proteins like Ag85 complex interact with host defenses to further complicate control of the disease. Another disorder linked to its infection is latent TB where the bacteria remain inactive but viable within the host posing ongoing public health challenges.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Mycobacterium tuberculosis

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Publications (34)

Recent publications for all applications. Explore the full list and refine your search

Journal of cytology 42:82-87 PubMed40520666

2025

Role of Immunocytochemistry in Detection of Antigen by Fine Needle Aspiration Cytology.

Applications

Unspecified application

Species

Unspecified reactive species

Pampa Ch Toi,Apoorvalakshmi Subramaniam,Noyal Mariya Joseph,Neelaiah Siddaraju

Science advances 11:eadq8158 PubMed39813329

2025

Single-cell analysis reveals ESX-1-mediated accumulation of permissive macrophages in infected mouse lungs.

Applications

Unspecified application

Species

Unspecified reactive species

Weihao Zheng,Michael Borja,Leah C Dorman,Jonathan Liu,Andy Zhou,Amanda Seng,Ritwicq Arjyal,Sara Sunshine,Alina Nalyvayko,Angela Oliveira Pisco,Oren S Rosenberg,Norma Neff,Beth Shoshana Zha

Tropical medicine and infectious disease 9: PubMed39591275

2024

Application of Monoclonal Anti-Mycolate Antibodies in Serological Diagnosis of Tuberculosis.

Applications

Unspecified application

Species

Unspecified reactive species

Alma Truyts,Ilse Du Preez,Eldas M Maesela,Manfred R Scriba,Les Baillie,Arwyn T Jones,Kevin J Land,Jan A Verschoor,Yolandy Lemmer

Diagnostic pathology 19:85 PubMed38907257

2024

Emerging human pulmonary dirofilariasis in Hungary: a single center experience.

Applications

Unspecified application

Species

Unspecified reactive species

Levente Kuthi,Tamás Zombori,László Tiszlavicz,Fanni Hegedűs,Szintia Almási,Bence Baráth,Mohammed Almakrami,Mohammad Jamal Ej,Nikolett Barta,Zsuzsanna Ujfaludi,Tibor Pankotai,Adrienn Hajdu,József Furák,Anita Sejben

Nature immunology 25:41-53 PubMed38036767

2023

BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Audrey Lee,Katharine Floyd,Shengyang Wu,Zhuoqing Fang,Tze Kai Tan,Heather M Froggatt,John M Powers,Sarah R Leist,Kendra L Gully,Miranda L Hubbard,Chunfeng Li,Harold Hui,David Scoville,Alistaire D Ruggiero,Yan Liang,Anna Pavenko,Victor Lujan,Ralph S Baric,Garry P Nolan,Prabhu S Arunachalam,Mehul S Suthar,Bali Pulendran

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 35:438-442 PubMed37204061

2023

Canine leproid granuloma caused by a member of the complex.

Applications

Unspecified application

Species

Unspecified reactive species

Federico Giannitti,Matías A Dorsch,Sofía Fernández-Ciganda,Ana Rabaza,Sebastián Vázquez,Deborah César,Joaquín Hurtado,Gonzalo Greif,Demi B Rabeneck,Julu Bhatnagar,Jana M Ritter

Nature communications 14:1430 PubMed36932056

2023

A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination.

Applications

Unspecified application

Species

Unspecified reactive species

Lihua Qiang,Yong Zhang,Zehui Lei,Zhe Lu,Shasha Tan,Pupu Ge,Qiyao Chai,Mengyuan Zhao,Xinwen Zhang,Bingxi Li,Yu Pang,Lingqiang Zhang,Cui Hua Liu,Jing Wang

The Journal of experimental medicine 220: PubMed36920308

2023

Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew J Sawyer,Ellis Patrick,Jarem Edwards,James S Wilmott,Timothy Fielder,Qianting Yang,Daniel L Barber,Joel D Ernst,Warwick J Britton,Umaimainthan Palendira,Xinchun Chen,Carl G Feng

Heliyon 8:e12370 PubMed36590545

2022

Utility of anti- antibody (ab905) for detection of mycobacterial antigens in formalin-fixed paraffin-embedded tissues from clinically and histologically suggestive extrapulmonary tuberculosis cases.

Applications

Unspecified application

Species

Unspecified reactive species

Samuel Ofori Addo,Afua Owusua Darkwah Abrahams,Gloria Ivy Mensah,Bernice Anane Mawuli,Lydia Mosi,Edwin Kwame Wiredu,Kennedy Kwasi Addo

The Journal of clinical investigation 132: PubMed36317628

2022

Stromal structure remodeling by B lymphocytes limits T cell activation in lymph nodes of Mycobacterium tuberculosis-infected mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lina Daniel,Nayan D Bhattacharyya,Claudio Counoupas,Yi Cai,Xinchun Chen,James A Triccas,Warwick J Britton,Carl G Feng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Mycobacterium tuberculosis antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mycobacterium tuberculosis antibody (AB905)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (34)

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